Myelodysplastic syndrome and acute leukaemia following treatment of soft tissue sarcoma

A de Graeff, C P Vendrik, H M Pinedo

Research output: Contribution to journalArticleAcademicpeer-review


The incidence of secondary myelodysplastic syndromes (MDS) and acute leukaemias (AL) after chemotherapy and/or radiotherapy is increasing. Most cases have been described in patients with Hodgkin's disease, non-Hodgkin's lymphomas, multiple myeloma, polycythemia vera, ovarian cancer and breast cancer. We report 2 patients with secondary MDS and acute myeloblastic leukaemia after combined chemotherapy and radiotherapy for soft tissue sarcoma. Five more cases have been described in the literature. The data of all patients are summarized. The occurrence of secondary MDS/AL in patients with soft tissue sarcoma may become a problem, in particular in children, who have been cured after combined radiotherapy and chemotherapy.

Original languageEnglish
Pages (from-to)251-7
Number of pages7
JournalNetherlands Journal of Medicine
Issue number5-6
Publication statusPublished - Jun 1989


  • Aged
  • Antineoplastic Agents
  • Combined Modality Therapy
  • Female
  • Humans
  • Leiomyosarcoma
  • Leukemia, Myeloid, Acute
  • Leukemia, Radiation-Induced
  • Liposarcoma
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes
  • Neoplasm Metastasis
  • Radiotherapy
  • Soft Tissue Neoplasms


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