Mycoplasma genitalium en España: prevalencia de infección genital y frecuencia de resistencia a macrólidos

Alejandra Asenjo; Johannes G Kusters; Tim T Severs; Juan-Ignacio Alós

doi:10.1016/j.eimc.2017.01.006

Mycoplasma genitalium en España: prevalencia de infección genital y frecuencia de resistencia a macrólidos

Translated title of the contribution: Mycoplasma genitalium in Spain: prevalence of genital infection and frequency of resistance to macrolides

Alejandra Asenjo, Johannes G Kusters, Tim T Severs, Juan-Ignacio Alós

Infection & Immunity

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015.

METHODS: We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced.

RESULTS: We found a prevalence of 3.34% of M. genitalium and a macrolide resistance rate of 20%. In males, the prevalence was 6.62% and in women 0.96%, being significantly higher in males.

CONCLUSIONS: The prevalence obtained shows that it is a pathogen to consider in our environment. These findings stress the need for routine testing of M. genitalium infections and would seem to suggest the advisability of resistance testing.

Translated title of the contribution	Mycoplasma genitalium in Spain: prevalence of genital infection and frequency of resistance to macrolides
Original language	Spanish
Pages (from-to)	169-171
Number of pages	3
Journal	Enfermedades Infecciosas y Microbiología Clínica
Volume	36
Issue number	3
Early online date	11 Mar 2017
DOIs	https://doi.org/10.1016/j.eimc.2017.01.006
Publication status	Published - Mar 2018

Keywords

Mycoplasma genitalium
Bacterial drug resistance
Epidemiology
Prevalence
Humans
Mycoplasma Infections/drug therapy
Drug Resistance, Bacterial
Male
Anti-Bacterial Agents/pharmacology
Mycoplasma genitalium/drug effects
Genital Diseases, Female/drug therapy
Macrolides/pharmacology
Young Adult
Genital Diseases, Male/drug therapy
Adult
Female

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10.1016/j.eimc.2017.01.006

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title = "Mycoplasma genitalium en Espa{\~n}a: prevalencia de infecci{\'o}n genital y frecuencia de resistencia a macr{\'o}lidos",

abstract = "INTRODUCTION: The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015.METHODS: We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced.RESULTS: We found a prevalence of 3.34% of M. genitalium and a macrolide resistance rate of 20%. In males, the prevalence was 6.62% and in women 0.96%, being significantly higher in males.CONCLUSIONS: The prevalence obtained shows that it is a pathogen to consider in our environment. These findings stress the need for routine testing of M. genitalium infections and would seem to suggest the advisability of resistance testing.",

keywords = "Mycoplasma genitalium, Bacterial drug resistance, Epidemiology, Prevalence, Humans, Mycoplasma Infections/drug therapy, Drug Resistance, Bacterial, Male, Anti-Bacterial Agents/pharmacology, Mycoplasma genitalium/drug effects, Genital Diseases, Female/drug therapy, Macrolides/pharmacology, Young Adult, Genital Diseases, Male/drug therapy, Adult, Female",

author = "Alejandra Asenjo and Kusters, {Johannes G} and Severs, {Tim T} and Juan-Ignacio Al{\'o}s",

year = "2018",

month = mar,

doi = "10.1016/j.eimc.2017.01.006",

language = "Spanish",

volume = "36",

pages = "169--171",

journal = "Enfermedades Infecciosas y Microbiolog{\'i}a Cl{\'i}nica",

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publisher = "Ediciones Doyma, S.L.",

number = "3",

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T1 - Mycoplasma genitalium en España

T2 - prevalencia de infección genital y frecuencia de resistencia a macrólidos

AU - Asenjo, Alejandra

AU - Kusters, Johannes G

AU - Severs, Tim T

AU - Alós, Juan-Ignacio

PY - 2018/3

Y1 - 2018/3

N2 - INTRODUCTION: The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015.METHODS: We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced.RESULTS: We found a prevalence of 3.34% of M. genitalium and a macrolide resistance rate of 20%. In males, the prevalence was 6.62% and in women 0.96%, being significantly higher in males.CONCLUSIONS: The prevalence obtained shows that it is a pathogen to consider in our environment. These findings stress the need for routine testing of M. genitalium infections and would seem to suggest the advisability of resistance testing.

AB - INTRODUCTION: The aim of this study was to determine the prevalence of Mycoplasma genitalium infection and the resistance to macrolides within a general population in Madrid in 2015.METHODS: We collected 359 urine samples from a general population with symptoms of sexually transmitted infections (STIs). All samples underwent a real-time PCR. For the detection of macrolide resistance, a 283bp fragment of region V of the 23S rRNA gene of M. genitalium was amplified and sequenced.RESULTS: We found a prevalence of 3.34% of M. genitalium and a macrolide resistance rate of 20%. In males, the prevalence was 6.62% and in women 0.96%, being significantly higher in males.CONCLUSIONS: The prevalence obtained shows that it is a pathogen to consider in our environment. These findings stress the need for routine testing of M. genitalium infections and would seem to suggest the advisability of resistance testing.

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KW - Bacterial drug resistance

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KW - Male

KW - Anti-Bacterial Agents/pharmacology

KW - Mycoplasma genitalium/drug effects

KW - Genital Diseases, Female/drug therapy

KW - Macrolides/pharmacology

KW - Young Adult

KW - Genital Diseases, Male/drug therapy

KW - Adult

KW - Female

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Mycoplasma genitalium en España: prevalencia de infección genital y frecuencia de resistencia a macrólidos

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