Mycobacterial factors relevant for transmission of tuberculosis

Lilly M Verhagen; Susan van den Hof; Henk van Deutekom; Peter W M Hermans; Kristin Kremer; Martien W Borgdorff; Dick van Soolingen

doi:10.1093/infdis/jir013

Mycobacterial factors relevant for transmission of tuberculosis

Lilly M Verhagen, Susan van den Hof, Henk van Deutekom, Peter W M Hermans, Kristin Kremer, Martien W Borgdorff, Dick van Soolingen

Physician assistant children

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Tuberculosis (TB) transmission is associated with patient-related risk factors. However, DNA fingerprint analysis has provided anecdotal evidence suggesting a role for bacteriological factors.

METHODS: To examine the importance of the bacteriological component in TB transmission, we investigated the number of tuberculin skin test-positive (TST induration, ≥ 10 mm) contacts and secondary cases observed in contact investigations around TB cases in relation to the size of the genotype cluster the patient belonged to at the time of diagnosis. We also compared the number of TST-positive contacts and secondary cases of patients with drug-resistant and drug-susceptible TB.

RESULTS: Larger clusters were independently associated with an increased number of positive contacts. The mean number of positive contacts ranged from 3.8 for clusters of 2 cases, to 4.7 for clusters of 3-10 cases, to 6.0 for cases in clusters of >10 cases (mean increase in number of positive contacts for every extra case in the cluster, 0.21; 95% confidence interval, 0.09-0.26). The mean number of positive contacts was significantly lower among index cases with isoniazid-monoresistant TB (1.6) than among index cases with pan-susceptible TB (4.6; relative number, 0.45; 95% confidence interval, 0.22-0.92).

CONCLUSION: These results suggest that spread of tuberculosis also depends on bacteriological factors.

Original language	English
Pages (from-to)	1249-55
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	203
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jir013
Publication status	Published - 2011

Keywords

Adult
Aged
Aged, 80 and over
Bacterial Typing Techniques
Cluster Analysis
Contact Tracing
DNA Fingerprinting
DNA, Bacterial
Female
Humans
Male
Middle Aged
Molecular Typing
Mycobacterium tuberculosis
Tuberculin Test
Tuberculosis
Virulence Factors
Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1093/infdis/jir013

Cite this

@article{1655f1e3e907418ba84138960a7ceffa,

title = "Mycobacterial factors relevant for transmission of tuberculosis",

abstract = "BACKGROUND: Tuberculosis (TB) transmission is associated with patient-related risk factors. However, DNA fingerprint analysis has provided anecdotal evidence suggesting a role for bacteriological factors.METHODS: To examine the importance of the bacteriological component in TB transmission, we investigated the number of tuberculin skin test-positive (TST induration, ≥ 10 mm) contacts and secondary cases observed in contact investigations around TB cases in relation to the size of the genotype cluster the patient belonged to at the time of diagnosis. We also compared the number of TST-positive contacts and secondary cases of patients with drug-resistant and drug-susceptible TB.RESULTS: Larger clusters were independently associated with an increased number of positive contacts. The mean number of positive contacts ranged from 3.8 for clusters of 2 cases, to 4.7 for clusters of 3-10 cases, to 6.0 for cases in clusters of >10 cases (mean increase in number of positive contacts for every extra case in the cluster, 0.21; 95% confidence interval, 0.09-0.26). The mean number of positive contacts was significantly lower among index cases with isoniazid-monoresistant TB (1.6) than among index cases with pan-susceptible TB (4.6; relative number, 0.45; 95% confidence interval, 0.22-0.92).CONCLUSION: These results suggest that spread of tuberculosis also depends on bacteriological factors.",

keywords = "Adult, Aged, Aged, 80 and over, Bacterial Typing Techniques, Cluster Analysis, Contact Tracing, DNA Fingerprinting, DNA, Bacterial, Female, Humans, Male, Middle Aged, Molecular Typing, Mycobacterium tuberculosis, Tuberculin Test, Tuberculosis, Virulence Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Verhagen, {Lilly M} and {van den Hof}, Susan and {van Deutekom}, Henk and Hermans, {Peter W M} and Kristin Kremer and Borgdorff, {Martien W} and {van Soolingen}, Dick",

year = "2011",

doi = "10.1093/infdis/jir013",

language = "English",

volume = "203",

pages = "1249--55",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "9",

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TY - JOUR

T1 - Mycobacterial factors relevant for transmission of tuberculosis

AU - Verhagen, Lilly M

AU - van den Hof, Susan

AU - van Deutekom, Henk

AU - Hermans, Peter W M

AU - Kremer, Kristin

AU - Borgdorff, Martien W

AU - van Soolingen, Dick

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Tuberculosis (TB) transmission is associated with patient-related risk factors. However, DNA fingerprint analysis has provided anecdotal evidence suggesting a role for bacteriological factors.METHODS: To examine the importance of the bacteriological component in TB transmission, we investigated the number of tuberculin skin test-positive (TST induration, ≥ 10 mm) contacts and secondary cases observed in contact investigations around TB cases in relation to the size of the genotype cluster the patient belonged to at the time of diagnosis. We also compared the number of TST-positive contacts and secondary cases of patients with drug-resistant and drug-susceptible TB.RESULTS: Larger clusters were independently associated with an increased number of positive contacts. The mean number of positive contacts ranged from 3.8 for clusters of 2 cases, to 4.7 for clusters of 3-10 cases, to 6.0 for cases in clusters of >10 cases (mean increase in number of positive contacts for every extra case in the cluster, 0.21; 95% confidence interval, 0.09-0.26). The mean number of positive contacts was significantly lower among index cases with isoniazid-monoresistant TB (1.6) than among index cases with pan-susceptible TB (4.6; relative number, 0.45; 95% confidence interval, 0.22-0.92).CONCLUSION: These results suggest that spread of tuberculosis also depends on bacteriological factors.

AB - BACKGROUND: Tuberculosis (TB) transmission is associated with patient-related risk factors. However, DNA fingerprint analysis has provided anecdotal evidence suggesting a role for bacteriological factors.METHODS: To examine the importance of the bacteriological component in TB transmission, we investigated the number of tuberculin skin test-positive (TST induration, ≥ 10 mm) contacts and secondary cases observed in contact investigations around TB cases in relation to the size of the genotype cluster the patient belonged to at the time of diagnosis. We also compared the number of TST-positive contacts and secondary cases of patients with drug-resistant and drug-susceptible TB.RESULTS: Larger clusters were independently associated with an increased number of positive contacts. The mean number of positive contacts ranged from 3.8 for clusters of 2 cases, to 4.7 for clusters of 3-10 cases, to 6.0 for cases in clusters of >10 cases (mean increase in number of positive contacts for every extra case in the cluster, 0.21; 95% confidence interval, 0.09-0.26). The mean number of positive contacts was significantly lower among index cases with isoniazid-monoresistant TB (1.6) than among index cases with pan-susceptible TB (4.6; relative number, 0.45; 95% confidence interval, 0.22-0.92).CONCLUSION: These results suggest that spread of tuberculosis also depends on bacteriological factors.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bacterial Typing Techniques

KW - Cluster Analysis

KW - Contact Tracing

KW - DNA Fingerprinting

KW - DNA, Bacterial

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Molecular Typing

KW - Mycobacterium tuberculosis

KW - Tuberculin Test

KW - Tuberculosis

KW - Virulence Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1093/infdis/jir013

DO - 10.1093/infdis/jir013

M3 - Article

C2 - 21378376

SN - 0022-1899

VL - 203

SP - 1249

EP - 1255

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 9

ER -