TY - JOUR
T1 - Multiplexed Nanobiosensors
T2 - Current Trends in Early Diagnostics
AU - Jarockyte, Greta
AU - Karabanovas, Vitalijus
AU - Rotomskis, Ricardas
AU - Mobasheri, Ali
N1 - Funding Information:
This research was funded by the European Regional Development Fund through the Research Council of Lithuania according to the Programme Attracting Foreign Researchers for Research Implementation, Grant No. 01.2.2-LMT-K-718?02-0022.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The ever-growing demand for fast, cheap, and reliable diagnostic tools for personalised medicine is encouraging scientists to improve existing technology platforms and to create new methods for the detection and quantification of biomarkers of clinical significance. Simultaneous detection of multiple analytes allows more accurate assessment of changes in biomarker expression and offers the possibility of disease diagnosis at the earliest stages. The concept of multiplexing, where multiple analytes can be detected in a single sample, can be tackled using several types of nanomaterial-based biosensors. Quantum dots are widely used photoluminescent nanoparticles and represent one of the most frequent choices for different multiplex systems. However, nanoparticles that incorporate gold, silver, and rare earth metals with their unique optical properties are an emerging perspective in the multiplexing field. In this review, we summarise progress in various nanoparticle applications for multiplexed biomarkers.
AB - The ever-growing demand for fast, cheap, and reliable diagnostic tools for personalised medicine is encouraging scientists to improve existing technology platforms and to create new methods for the detection and quantification of biomarkers of clinical significance. Simultaneous detection of multiple analytes allows more accurate assessment of changes in biomarker expression and offers the possibility of disease diagnosis at the earliest stages. The concept of multiplexing, where multiple analytes can be detected in a single sample, can be tackled using several types of nanomaterial-based biosensors. Quantum dots are widely used photoluminescent nanoparticles and represent one of the most frequent choices for different multiplex systems. However, nanoparticles that incorporate gold, silver, and rare earth metals with their unique optical properties are an emerging perspective in the multiplexing field. In this review, we summarise progress in various nanoparticle applications for multiplexed biomarkers.
KW - Gold nanoparticles
KW - Multiplexing
KW - Nanoparticles
KW - Quantum dots
KW - Silver nanoparticles
KW - Upconverting nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85097272860&partnerID=8YFLogxK
U2 - 10.3390/s20236890
DO - 10.3390/s20236890
M3 - Review article
C2 - 33276535
SN - 1424-8220
VL - 20
SP - 1
EP - 23
JO - Sensors (Basel, Switzerland)
JF - Sensors (Basel, Switzerland)
IS - 23
M1 - 6890
ER -