Multifactorial Prevention of Cardiovascular Disease in Patients with Hypertension: the Cardiovascular Polypill

M Lafeber, W Spiering*, F L J Visseren, D E Grobbee

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Hypertension is a major, if not the most important, contributor to the disease burden and premature death globally which is largely related to cardiovascular disease. In both the primary and the secondary preventions of cardiovascular disease, blood pressure (BP) targets are often not achieved which is similar to achievement of cholesterol goals. Combining aspirin, cholesterol and blood pressure-lowering agents into a fixed-dose combination pill called the cardiovascular polypill has been proposed as complementary care in the prevention of cardiovascular diseases in both the primary and secondary preventions of cardiovascular disease. This review article focuses on the potential role of fixed-dose combination therapy in the treatment of hypertension, outlines the pros and cons of combination therapy and emphasizes the rationale for trialling their use. Current and planned future cardiovascular polypill trials are summarized, and the prerequisites for implementation of the polypill strategy are described.

Original languageEnglish
Article number18:40
JournalCurrent Hypertension Reports
Volume18
Issue number5
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • Adherence
  • Cholesterol
  • Combination pill
  • Fixed-dose combination therapy
  • Hypertension
  • Polypill
  • Prevention

Fingerprint

Dive into the research topics of 'Multifactorial Prevention of Cardiovascular Disease in Patients with Hypertension: the Cardiovascular Polypill'. Together they form a unique fingerprint.

Cite this