Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method

A Espinel-Ingroff; A Chowdhary; G M Gonzalez; J Guinea; F Hagen; J F Meis; G R Thompson; J Turnidge

doi:10.1128/AAC.04055-14

Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method

A Espinel-Ingroff
, A Chowdhary
, G M Gonzalez
, J Guinea
, F Hagen
, J F Meis
, G R Thompson
, J Turnidge

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.

Original language	English
Pages (from-to)	666-8
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	1
DOIs	https://doi.org/10.1128/AAC.04055-14
Publication status	Published - Jan 2015
Externally published	Yes

Keywords

Antifungal Agents/pharmacology
Cryptococcosis/drug therapy
Cryptococcus gattii/drug effects
Cryptococcus neoformans/drug effects
Genotype
Humans
Microbial Sensitivity Tests
Nitriles/pharmacology
Pyridines/pharmacology
Triazoles/pharmacology

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10.1128/AAC.04055-14

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Espinel-Ingroff, A., Chowdhary, A., Gonzalez, G. M., Guinea, J., Hagen, F., Meis, J. F., Thompson, G. R., & Turnidge, J. (2015). Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method. Antimicrobial Agents and Chemotherapy, 59(1), 666-8. https://doi.org/10.1128/AAC.04055-14

@article{ddb9132dd0164794bbe4dc6ee5b3400e,

title = "Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method",

abstract = "Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.",

keywords = "Antifungal Agents/pharmacology, Cryptococcosis/drug therapy, Cryptococcus gattii/drug effects, Cryptococcus neoformans/drug effects, Genotype, Humans, Microbial Sensitivity Tests, Nitriles/pharmacology, Pyridines/pharmacology, Triazoles/pharmacology",

author = "A Espinel-Ingroff and A Chowdhary and Gonzalez, \{G M\} and J Guinea and F Hagen and Meis, \{J F\} and Thompson, \{G R\} and J Turnidge",

year = "2015",

month = jan,

doi = "10.1128/AAC.04055-14",

language = "English",

volume = "59",

pages = "666--8",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

Espinel-Ingroff, A, Chowdhary, A, Gonzalez, GM, Guinea, J, Hagen, F, Meis, JF, Thompson, GR & Turnidge, J 2015, 'Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method', Antimicrobial Agents and Chemotherapy, vol. 59, no. 1, pp. 666-8. https://doi.org/10.1128/AAC.04055-14

Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method. / Espinel-Ingroff, A; Chowdhary, A; Gonzalez, G M et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 1, 01.2015, p. 666-8.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method

AU - Espinel-Ingroff, A

AU - Chowdhary, A

AU - Gonzalez, G M

AU - Guinea, J

AU - Hagen, F

AU - Meis, J F

AU - Thompson, G R

AU - Turnidge, J

PY - 2015/1

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N2 - Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.

AB - Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.

KW - Antifungal Agents/pharmacology

KW - Cryptococcosis/drug therapy

KW - Cryptococcus gattii/drug effects

KW - Cryptococcus neoformans/drug effects

KW - Genotype

KW - Humans

KW - Microbial Sensitivity Tests

KW - Nitriles/pharmacology

KW - Pyridines/pharmacology

KW - Triazoles/pharmacology

U2 - 10.1128/AAC.04055-14

DO - 10.1128/AAC.04055-14

M3 - Article

C2 - 25313209

SN - 0066-4804

VL - 59

SP - 666

EP - 668

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

ER -

Espinel-Ingroff A, Chowdhary A, Gonzalez GM, Guinea J, Hagen F, Meis JF et al. Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method. Antimicrobial Agents and Chemotherapy. 2015 Jan;59(1):666-8. doi: 10.1128/AAC.04055-14

Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method

Abstract

Keywords

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