Multicenter studies and harmonization: Problems, solutions, and open challenges

Chantal M.W. Tax; Suheyla Cetin Karayumak; Kurt G. Schilling; Daniel Moyer; Bennett A. Landman; Neda Jahanshad; Yogesh Rathi

doi:10.1016/B978-0-12-818894-1.00039-2

Multicenter studies and harmonization: Problems, solutions, and open challenges

Chantal M.W. Tax, Suheyla Cetin Karayumak, Kurt G. Schilling, Daniel Moyer, Bennett A. Landman, Neda Jahanshad, Yogesh Rathi

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Combining diffusion magnetic resonance imaging (dMRI) across scanners and sites can improve our understanding of the human brain in health and disease, but variability in the data challenges the joint analysis of different datasets. This chapter focuses on the sources of variability in multicenter studies, solutions that have been proposed to deal with variability in joint analyses, and open challenges in the era of “big data” for dMRI and tractography.

Original language	English
Title of host publication	Handbook of Diffusion MR Tractography
Subtitle of host publication	Imaging Methods, Biophysical Models, Algorithms and Applications
Publisher	Elsevier
Chapter	33
Pages	669-688
Number of pages	20
ISBN (Electronic)	9780128188941
ISBN (Print)	9780128188958
DOIs	https://doi.org/10.1016/B978-0-12-818894-1.00039-2
Publication status	Published - Jan 2025

Keywords

Harmonization
Measurement variability

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10.1016/B978-0-12-818894-1.00039-2

Cite this

Tax, C. M. W., Karayumak, S. C., Schilling, K. G., Moyer, D., Landman, B. A., Jahanshad, N., & Rathi, Y. (2025). Multicenter studies and harmonization: Problems, solutions, and open challenges. In Handbook of Diffusion MR Tractography: Imaging Methods, Biophysical Models, Algorithms and Applications (pp. 669-688). Elsevier. https://doi.org/10.1016/B978-0-12-818894-1.00039-2

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Multicenter studies and harmonization: Problems, solutions, and open challenges. / Tax, Chantal M.W.; Karayumak, Suheyla Cetin; Schilling, Kurt G. et al.
Handbook of Diffusion MR Tractography: Imaging Methods, Biophysical Models, Algorithms and Applications. Elsevier, 2025. p. 669-688.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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AU - Tax, Chantal M.W.

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AU - Schilling, Kurt G.

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Multicenter studies and harmonization: Problems, solutions, and open challenges

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Keywords

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