Multi-level clustering in sarcoidosis: A preliminary study

V. L.J. Karthaus*, H. H.L.M. Donkers, J. C. Grutters, H. J. Van Den Herik, J. M.M. Van Den Bosch

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Sarcoidosis is a multisystem disorder that is characterized by the formation of granulomas in certain organs of the body. The exact cause of sarcoidosis is unknown but evidence exists that sarcoidosis results from exposure of genetically susceptible hosts to specific environmental agents. The wide degree of clinical heterogeneity might indicate that sarcoidosis is not a single polymorphic disease but a collection of genetically complex diseases. As a first step to identify the hypothesized subcategories, large amounts of multidimensional data are collected that are divided into distinct levels. We investigated how clustering techniques can be applied to support the interpretation of sarcoidosis and subsequently to reveal categories of sarcoidosis data. An attempt is made to relate multiple clusters between the different data levels based on validation criteria.

Original languageEnglish
Title of host publicationArtificial Intelligence in Medicine - 11th Conference on Artificial Intelligence in Medicine, AIME 2007, Proceedings
PublisherSpringer-Verlag
Pages200-204
Number of pages5
ISBN (Print)3540735984, 9783540735984
DOIs
Publication statusPublished - 2007
Externally publishedYes
Event11th Conference on Artificial Intelligence in Medicine, AIME 2007 - Amsterdam, Netherlands
Duration: 7 Jul 200711 Jul 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4594 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th Conference on Artificial Intelligence in Medicine, AIME 2007
Country/TerritoryNetherlands
CityAmsterdam
Period7/07/0711/07/07

Keywords

  • Clustering
  • Sarcoidosis

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