@article{71a4877ce1da4c49ab142a41041c5682,
title = "MRI Visualization of Injectable Ureidopyrimidinone Hydrogelators by Supramolecular Contrast Agent Labeling",
abstract = "Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.",
keywords = "Catheters, Gadolinium, Injectable hydrogels, MRI, Ureidopyrimidinone",
author = "Bakker, {Maarten H.} and Tseng, {Cheyenne C.S.} and Keizer, {Henk M.} and Seevinck, {Peter R.} and Janssen, {Henk M.} and {Van Slochteren}, {Frebus J.} and Chamuleau, {Steven A.J.} and Dankers, {Patricia Y.W.}",
note = "Funding Information: M.H.B. and C.C.S.T. contributed equally to this work. This work was supported by the Ministry of Education, Culture and Science (Gravity Program 024.001.035) and the European Research Council (FP7/2007-2013) ERC Grant Agreement 308045. Part of the research was conducted by the MIGRATE consortium within the TKI LSH framework and with financial support of the Hartstichting and Netherlands Heart Foundation. The authors thank Thijs van den Broek, Peter-Paul Fransen, and Jurgen Schill for their contributions. Publisher Copyright: {\textcopyright} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = jun,
doi = "10.1002/adhm.201701139",
language = "English",
volume = "7",
journal = "Advanced Healthcare Materials",
issn = "2192-2640",
publisher = "John Wiley & Sons Inc.",
number = "11",
}