MR imaging for accurate prediction of outcome after perinatal arterial ischemic stroke: Sooner not necessarily better

Nienke Wagenaar; Niek E van der Aa; Floris Groenendaal; Cornelia H  Verhage; Manon J N L Benders; Linda S de Vries

doi:10.1016/j.ejpn.2017.04.002

MR imaging for accurate prediction of outcome after perinatal arterial ischemic stroke: Sooner not necessarily better

Nienke Wagenaar, Niek E van der Aa, Floris Groenendaal, Cornelia H Verhage, Manon J N L Benders, Linda S de Vries

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Involvement of the corticospinal tracts after perinatal arterial ischemic stroke (PAIS) is strongly correlated with adverse motor outcome.

METHODS: Two full-term infants with PAIS, with two early MRI scans available, are reported.

RESULTS: Diffusion weighted imaging (DWI)-MRI, performed within 24 h following onset of seizures and repeated 48 h later, clearly showed restricted diffusion within the middle cerebral artery territory on both MRIs, but clear patterns of signal intensity changes in the descending corticospinal tracts on the second MRI only.

CONCLUSION: Since involvement of the corticospinal tracts is essential for prediction of motor outcome, we may need to reconsider optimal timing of MR imaging for prediction of neurodevelopmental outcome after PAIS.

Original language	English
Pages (from-to)	666–670
Number of pages	5
Journal	European Journal of Paediatric Neurology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.ejpn.2017.04.002
Publication status	Published - Jul 2017

Keywords

Corticospinal tract
MRI
Neonate
PAIS
Stroke
Wallerian

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title = "MR imaging for accurate prediction of outcome after perinatal arterial ischemic stroke: Sooner not necessarily better",

abstract = "BACKGROUND: Involvement of the corticospinal tracts after perinatal arterial ischemic stroke (PAIS) is strongly correlated with adverse motor outcome.METHODS: Two full-term infants with PAIS, with two early MRI scans available, are reported.RESULTS: Diffusion weighted imaging (DWI)-MRI, performed within 24 h following onset of seizures and repeated 48 h later, clearly showed restricted diffusion within the middle cerebral artery territory on both MRIs, but clear patterns of signal intensity changes in the descending corticospinal tracts on the second MRI only.CONCLUSION: Since involvement of the corticospinal tracts is essential for prediction of motor outcome, we may need to reconsider optimal timing of MR imaging for prediction of neurodevelopmental outcome after PAIS.",

keywords = "Corticospinal tract, MRI, Neonate, PAIS, Stroke, Wallerian",

author = "Nienke Wagenaar and {van der Aa}, {Niek E} and Floris Groenendaal and Verhage, {Cornelia H} and Benders, {Manon J N L} and {de Vries}, {Linda S}",

note = "Publisher Copyright: {\textcopyright} 2017 European Paediatric Neurology Society",

year = "2017",

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doi = "10.1016/j.ejpn.2017.04.002",

language = "English",

volume = "21",

pages = "666–670",

journal = "European Journal of Paediatric Neurology",

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publisher = "W.B. Saunders Ltd",

number = "4",

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TY - JOUR

T1 - MR imaging for accurate prediction of outcome after perinatal arterial ischemic stroke

T2 - Sooner not necessarily better

AU - Wagenaar, Nienke

AU - van der Aa, Niek E

AU - Groenendaal, Floris

AU - Verhage, Cornelia H

AU - Benders, Manon J N L

AU - de Vries, Linda S

PY - 2017/7

Y1 - 2017/7

N2 - BACKGROUND: Involvement of the corticospinal tracts after perinatal arterial ischemic stroke (PAIS) is strongly correlated with adverse motor outcome.METHODS: Two full-term infants with PAIS, with two early MRI scans available, are reported.RESULTS: Diffusion weighted imaging (DWI)-MRI, performed within 24 h following onset of seizures and repeated 48 h later, clearly showed restricted diffusion within the middle cerebral artery territory on both MRIs, but clear patterns of signal intensity changes in the descending corticospinal tracts on the second MRI only.CONCLUSION: Since involvement of the corticospinal tracts is essential for prediction of motor outcome, we may need to reconsider optimal timing of MR imaging for prediction of neurodevelopmental outcome after PAIS.

AB - BACKGROUND: Involvement of the corticospinal tracts after perinatal arterial ischemic stroke (PAIS) is strongly correlated with adverse motor outcome.METHODS: Two full-term infants with PAIS, with two early MRI scans available, are reported.RESULTS: Diffusion weighted imaging (DWI)-MRI, performed within 24 h following onset of seizures and repeated 48 h later, clearly showed restricted diffusion within the middle cerebral artery territory on both MRIs, but clear patterns of signal intensity changes in the descending corticospinal tracts on the second MRI only.CONCLUSION: Since involvement of the corticospinal tracts is essential for prediction of motor outcome, we may need to reconsider optimal timing of MR imaging for prediction of neurodevelopmental outcome after PAIS.

KW - Corticospinal tract

KW - MRI

KW - Neonate

KW - PAIS

KW - Stroke

KW - Wallerian

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DO - 10.1016/j.ejpn.2017.04.002

M3 - Article

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SN - 1090-3798

VL - 21

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EP - 670

JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

IS - 4

ER -

MR imaging for accurate prediction of outcome after perinatal arterial ischemic stroke: Sooner not necessarily better

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