Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites

Debby Bogaert; Gina J. van Beveren; Emma M. de Koff; Paula Lusarreta Parga; Carlos E. Balcazar Lopez; Lilian Koppensteiner; Melanie Clerc; Raiza Hasrat; Kayleigh Arp; Mei Ling J.N. Chu; Pieter C.M. de Groot; Elisabeth A.M. Sanders; Marlies A. van Houten; Wouter A.A. de Steenhuijsen Piters

doi:10.1016/j.chom.2023.01.018

Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites

Debby Bogaert^*, Gina J. van Beveren, Emma M. de Koff, Paula Lusarreta Parga, Carlos E. Balcazar Lopez, Lilian Koppensteiner, Melanie Clerc, Raiza Hasrat, Kayleigh Arp, Mei Ling J.N. Chu, Pieter C.M. de Groot, Elisabeth A.M. Sanders, Marlies A. van Houten, Wouter A.A. de Steenhuijsen Piters^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in 120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche-specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk microbiota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes.

Original language	English
Pages (from-to)	447-460.e6
Journal	Cell Host and Microbe
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2023.01.018
Publication status	Published - 8 Mar 2023

Keywords

16S-rRNA sequencing
Bacteroides
cesarean section
development
early-life
heritability
microbiome
microbiota
mother-infant transmission
seeding

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10.1016/j.chom.2023.01.018

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Bogaert, D., van Beveren, G. J., de Koff, E. M., Lusarreta Parga, P., Balcazar Lopez, C. E., Koppensteiner, L., Clerc, M., Hasrat, R., Arp, K., Chu, M. L. J. N., de Groot, P. C. M., Sanders, E. A. M., van Houten, M. A., & de Steenhuijsen Piters, W. A. A. (2023). Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites. Cell Host and Microbe, 31(3), 447-460.e6. https://doi.org/10.1016/j.chom.2023.01.018

@article{f22e606ab718428eb9d95eb9bc355fda,

title = "Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites",

abstract = "Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in 120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche-specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk microbiota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes.",

keywords = "16S-rRNA sequencing, Bacteroides, cesarean section, development, early-life, heritability, microbiome, microbiota, mother-infant transmission, seeding",

author = "Debby Bogaert and {van Beveren}, {Gina J.} and {de Koff}, {Emma M.} and {Lusarreta Parga}, Paula and {Balcazar Lopez}, {Carlos E.} and Lilian Koppensteiner and Melanie Clerc and Raiza Hasrat and Kayleigh Arp and Chu, {Mei Ling J.N.} and {de Groot}, {Pieter C.M.} and Sanders, {Elisabeth A.M.} and {van Houten}, {Marlies A.} and {de Steenhuijsen Piters}, {Wouter A.A.}",

note = "Funding Information: The authors would like to thank all families who participated in this study. We are indebted to Astrid A.T.M. Bosch and all members of the Spaarne Gasthuis Academy research team for their dedication and practical support with participant enrollment and sample collection. This work was supported in part by the Dutch Research Council (NWO)_ through a VIDI-grant ( 91715359 ) and CSO/NRS through a Scottish Senior Clinical Fellowship award ( SCAF/16/03 ). Funding Information: D.B. received funding from OM Pharma and GlaxoSmithKline for studies unrelated to this work. Funding Information: The authors would like to thank all families who participated in this study. We are indebted to Astrid A.T.M. Bosch and all members of the Spaarne Gasthuis Academy research team for their dedication and practical support with participant enrollment and sample collection. This work was supported in part by the Dutch Research Council (NWO)_ through a VIDI-grant(91715359) and CSO/NRS through a Scottish Senior Clinical Fellowship award (SCAF/16/03). Conceptualization, D.B. M.A.v.H. and E.A.M.S.; resources, M.A.v.H. and P.C.M.d.G.; investigation, R.H. K.A. P.L.P. C.E.B.L. L.K. M.C. and M.L.J.N.C.; formal analysis, G.J.v.B. E.M.d.K. and W.A.A.d.S.P.; visualization, W.A.A.d.S.P.; writing – original draft, D.B. and W.A.A.d.S.P.; writing – review & editing, all authors; supervision, M.A.v.H. P.C.M.d.G. D.B. and W.A.A.d.S.P.; funding acquisition, D.B. D.B. received funding from OM Pharma and GlaxoSmithKline for studies unrelated to this work. We support inclusive, diverse, and equitable conduct of research. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = mar,

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doi = "10.1016/j.chom.2023.01.018",

language = "English",

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Bogaert, D, van Beveren, GJ, de Koff, EM, Lusarreta Parga, P, Balcazar Lopez, CE, Koppensteiner, L, Clerc, M, Hasrat, R, Arp, K, Chu, MLJN, de Groot, PCM, Sanders, EAM, van Houten, MA & de Steenhuijsen Piters, WAA 2023, 'Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites', Cell Host and Microbe, vol. 31, no. 3, pp. 447-460.e6. https://doi.org/10.1016/j.chom.2023.01.018

TY - JOUR

T1 - Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites

AU - Bogaert, Debby

AU - van Beveren, Gina J.

AU - de Koff, Emma M.

AU - Lusarreta Parga, Paula

AU - Balcazar Lopez, Carlos E.

AU - Koppensteiner, Lilian

AU - Clerc, Melanie

AU - Hasrat, Raiza

AU - Arp, Kayleigh

AU - Chu, Mei Ling J.N.

AU - de Groot, Pieter C.M.

AU - Sanders, Elisabeth A.M.

AU - van Houten, Marlies A.

AU - de Steenhuijsen Piters, Wouter A.A.

N1 - Funding Information: The authors would like to thank all families who participated in this study. We are indebted to Astrid A.T.M. Bosch and all members of the Spaarne Gasthuis Academy research team for their dedication and practical support with participant enrollment and sample collection. This work was supported in part by the Dutch Research Council (NWO)_ through a VIDI-grant ( 91715359 ) and CSO/NRS through a Scottish Senior Clinical Fellowship award ( SCAF/16/03 ). Funding Information: D.B. received funding from OM Pharma and GlaxoSmithKline for studies unrelated to this work. Funding Information: The authors would like to thank all families who participated in this study. We are indebted to Astrid A.T.M. Bosch and all members of the Spaarne Gasthuis Academy research team for their dedication and practical support with participant enrollment and sample collection. This work was supported in part by the Dutch Research Council (NWO)_ through a VIDI-grant(91715359) and CSO/NRS through a Scottish Senior Clinical Fellowship award (SCAF/16/03). Conceptualization, D.B. M.A.v.H. and E.A.M.S.; resources, M.A.v.H. and P.C.M.d.G.; investigation, R.H. K.A. P.L.P. C.E.B.L. L.K. M.C. and M.L.J.N.C.; formal analysis, G.J.v.B. E.M.d.K. and W.A.A.d.S.P.; visualization, W.A.A.d.S.P.; writing – original draft, D.B. and W.A.A.d.S.P.; writing – review & editing, all authors; supervision, M.A.v.H. P.C.M.d.G. D.B. and W.A.A.d.S.P.; funding acquisition, D.B. D.B. received funding from OM Pharma and GlaxoSmithKline for studies unrelated to this work. We support inclusive, diverse, and equitable conduct of research. Publisher Copyright: © 2023 Elsevier Inc.

PY - 2023/3/8

Y1 - 2023/3/8

N2 - Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in 120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche-specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk microbiota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes.

AB - Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in 120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche-specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk microbiota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes.

KW - 16S-rRNA sequencing

KW - Bacteroides

KW - cesarean section

KW - development

KW - early-life

KW - heritability

KW - microbiome

KW - microbiota

KW - mother-infant transmission

KW - seeding

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U2 - 10.1016/j.chom.2023.01.018

DO - 10.1016/j.chom.2023.01.018

M3 - Article

C2 - 36893737

AN - SCOPUS:85149636940

SN - 1931-3128

VL - 31

SP - 447-460.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 3

ER -

Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites

Abstract

Keywords

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