TY - JOUR
T1 - Monitoring of blood-10b concentration for boron neutron capture therapy using prompt gamma-ray analysis
AU - Raaijmakers, Cornelis P.J.
AU - Konijnenberg, Mark W.
AU - Dewit, Luc
AU - Haritz, Dietrich
AU - Huiskamp, Rene
AU - Philipp, Katharina
AU - Siefert, Axel
AU - Stecher-Rasmussen, Finn
AU - Mijnheer, Ben J.
N1 - Funding Information:
This work was financially supported by a grant of the Netherlands Cancer Foundation (NKB Grant NKI 90-03).
PY - 1995
Y1 - 1995
N2 - The aim of the present study was to monitor the blood-10B concentration of laboratory dogs receiving boron neutron capture therapy, in order to obtain optimal agreement between prescribed and actual dose. A prompt gamma-ray analysis system was developed for this purpose at the High Flux Reactor in Petten. The technique was compared with inductively coupled plasma-atomic emission spectrometry and showed good agreement. A substantial variation in 10B clearance pattern after administration of borocaptate sodium was found between the different dogs. Consequently, the irradiation commencement was adjusted to the individually determined boron elimination curve. Mean blood-10B concentrations during irradiation of 25.8 ± 2.2 μg/g (1 SD, n = 18) and 49.3 ± 5.3 μg/g (1 SD, n = 17) were obtained for intended concentrations of 25 μg/g and 50 μg/g, respectively. These variations are a factor of two smaller than irradiations performed at a uniform post-infusion irradiation starting time. Such a careful blood-10B monitoring procedure is a prerequisite for accurately obtaining such steep dose-response curves as observed during the dog study.
AB - The aim of the present study was to monitor the blood-10B concentration of laboratory dogs receiving boron neutron capture therapy, in order to obtain optimal agreement between prescribed and actual dose. A prompt gamma-ray analysis system was developed for this purpose at the High Flux Reactor in Petten. The technique was compared with inductively coupled plasma-atomic emission spectrometry and showed good agreement. A substantial variation in 10B clearance pattern after administration of borocaptate sodium was found between the different dogs. Consequently, the irradiation commencement was adjusted to the individually determined boron elimination curve. Mean blood-10B concentrations during irradiation of 25.8 ± 2.2 μg/g (1 SD, n = 18) and 49.3 ± 5.3 μg/g (1 SD, n = 17) were obtained for intended concentrations of 25 μg/g and 50 μg/g, respectively. These variations are a factor of two smaller than irradiations performed at a uniform post-infusion irradiation starting time. Such a careful blood-10B monitoring procedure is a prerequisite for accurately obtaining such steep dose-response curves as observed during the dog study.
UR - http://www.scopus.com/inward/record.url?scp=0028980149&partnerID=8YFLogxK
U2 - 10.3109/02841869509094017
DO - 10.3109/02841869509094017
M3 - Article
C2 - 7605661
AN - SCOPUS:0028980149
SN - 0284-186X
VL - 34
SP - 517
EP - 523
JO - Acta Oncologica
JF - Acta Oncologica
IS - 4
ER -