Molecular regulation of microlymphatic formation and function: Role of nitric oxide

J Hagendoorn; TP Padera; D Fukumura; RK Jain

doi:10.1016/j.tcm.2005.06.003

Molecular regulation of microlymphatic formation and function: Role of nitric oxide

J Hagendoorn, TP Padera, D Fukumura, RK Jain^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Inhibition of lymphangiogenesis prevents lymphatic cancer metastasis, whereas induction of lymphangiogenesis alleviates lymphedema in experimental animal models. The number of known molecular players that govern the formation and function of the microlymphatic system is growing. Here, we review the role of nitric oxide within the regulation of lymphatic formation and function and point out key unanswered questions for its translation into clinical therapy.

Original language	English
Article number	PII S1050-1738(05)00084-8
Pages (from-to)	169-173
Number of pages	5
Journal	Trends in Cardiovascular Medicine
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.tcm.2005.06.003
Publication status	Published - Jul 2005
Externally published	Yes

Keywords

GROWTH-FACTOR-C
LYMPHATIC ENDOTHELIAL-CELLS
PROGENITOR CELLS
TISSUE ISCHEMIA
IN-VIVO
SYNTHASE
LYMPHANGIOGENESIS
ANGIOGENESIS
METASTASIS
VESSELS

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10.1016/j.tcm.2005.06.003

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title = "Molecular regulation of microlymphatic formation and function: Role of nitric oxide",

abstract = "Inhibition of lymphangiogenesis prevents lymphatic cancer metastasis, whereas induction of lymphangiogenesis alleviates lymphedema in experimental animal models. The number of known molecular players that govern the formation and function of the microlymphatic system is growing. Here, we review the role of nitric oxide within the regulation of lymphatic formation and function and point out key unanswered questions for its translation into clinical therapy.",

keywords = "GROWTH-FACTOR-C, LYMPHATIC ENDOTHELIAL-CELLS, PROGENITOR CELLS, TISSUE ISCHEMIA, IN-VIVO, SYNTHASE, LYMPHANGIOGENESIS, ANGIOGENESIS, METASTASIS, VESSELS",

author = "J Hagendoorn and TP Padera and D Fukumura and RK Jain",

year = "2005",

month = jul,

doi = "10.1016/j.tcm.2005.06.003",

language = "English",

volume = "15",

pages = "169--173",

journal = "Trends in Cardiovascular Medicine",

issn = "1050-1738",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Molecular regulation of microlymphatic formation and function

T2 - Role of nitric oxide

AU - Hagendoorn, J

AU - Padera, TP

AU - Fukumura, D

AU - Jain, RK

PY - 2005/7

Y1 - 2005/7

N2 - Inhibition of lymphangiogenesis prevents lymphatic cancer metastasis, whereas induction of lymphangiogenesis alleviates lymphedema in experimental animal models. The number of known molecular players that govern the formation and function of the microlymphatic system is growing. Here, we review the role of nitric oxide within the regulation of lymphatic formation and function and point out key unanswered questions for its translation into clinical therapy.

AB - Inhibition of lymphangiogenesis prevents lymphatic cancer metastasis, whereas induction of lymphangiogenesis alleviates lymphedema in experimental animal models. The number of known molecular players that govern the formation and function of the microlymphatic system is growing. Here, we review the role of nitric oxide within the regulation of lymphatic formation and function and point out key unanswered questions for its translation into clinical therapy.

KW - GROWTH-FACTOR-C

KW - LYMPHATIC ENDOTHELIAL-CELLS

KW - PROGENITOR CELLS

KW - TISSUE ISCHEMIA

KW - IN-VIVO

KW - SYNTHASE

KW - LYMPHANGIOGENESIS

KW - ANGIOGENESIS

KW - METASTASIS

KW - VESSELS

U2 - 10.1016/j.tcm.2005.06.003

DO - 10.1016/j.tcm.2005.06.003

M3 - Review article

C2 - 16165013

SN - 1050-1738

VL - 15

SP - 169

EP - 173

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 5

M1 - PII S1050-1738(05)00084-8

ER -

Molecular regulation of microlymphatic formation and function: Role of nitric oxide

Abstract

Keywords

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