Abstract
The complement system is a crucial component of the innate immune
response in humans. Recent studies in Staphylococcus aureus and Neisseria
meningitidis have revealed how these bacteria escape complement-mediated
killing. In addition, new structural data have provided detailed insights into the
molecular mechanisms of host defence mediated by the complement system and
how bacterial proteins interfere with this process. This information is fundamental
to our understanding of bacterial pathogenesis and may facilitate the design of
better vaccines.
| Translated title of the contribution | Molecular mechanisms of complement evasion: learning from staphylococci and meningococci |
|---|---|
| Original language | Undefined/Unknown |
| Pages (from-to) | 393-399 |
| Number of pages | 7 |
| Journal | Nature Reviews. Microbiology |
| Volume | 8 |
| Publication status | Published - 2010 |