Molecular genetics of pancreatic carcinogenesis and their clinical significance

N.A. Ottenhof

Molecular genetics of pancreatic carcinogenesis and their clinical significance

N.A. Ottenhof

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

Like all types of cancer, pancreatic ductal adenocarcinoma (PDAC), the most common pancreatic malignancy, is a disease of the genes and the genetic alterations that are involved in the development of PDAC have been under investigation for many years. The research described in this thesis focuses on these genetic alterations and their clinical relevance. In order to provide an overview of the current insights in pancreatic carcinogenesis, the review articles in Chapter 3 and Chapter 4 are included. In Chapter 5, multivariate analysis was conducted investigating the effects on survival of both clinical and histological features of PDAC. The study showed that lymph node ratio

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Utrecht University
Supervisors/Advisors	Offerhaus, G.J.A., Primary supervisor, External person van Noorden, C.J.F., Supervisor, External person Maitra, A., Supervisor, External person
Award date	6 Sept 2012
Place of Publication	's-Hertogenbosch
Publisher	Uitgeverij BOXPress
Print ISBNs	978-90-889-1448-5
Publication status	Published - 6 Sept 2012

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AB - Like all types of cancer, pancreatic ductal adenocarcinoma (PDAC), the most common pancreatic malignancy, is a disease of the genes and the genetic alterations that are involved in the development of PDAC have been under investigation for many years. The research described in this thesis focuses on these genetic alterations and their clinical relevance. In order to provide an overview of the current insights in pancreatic carcinogenesis, the review articles in Chapter 3 and Chapter 4 are included. In Chapter 5, multivariate analysis was conducted investigating the effects on survival of both clinical and histological features of PDAC. The study showed that lymph node ratio

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-90-889-1448-5

PB - Uitgeverij BOXPress

CY - 's-Hertogenbosch

ER -

Molecular genetics of pancreatic carcinogenesis and their clinical significance

Abstract

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