Molecular diagnostics in pathology

J. W.J. Hinrichs; R. A. de Weger; W. T.M. van Blokland; G. J.A. Offerhaus; P. J. van Diest

doi:10.1007/978-981-10-4511-0_5

Molecular diagnostics in pathology

J. W.J. Hinrichs^*, R. A. de Weger, W. T.M. van Blokland, G. J.A. Offerhaus, P. J. van Diest

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Molecular diagnostics is a rapidly growing discipline within pathology. This is largely explained by the changes in cancer treatment in the last decade. More and more types of cancer can be linked to specific DNA abnormalities and qualify for so-called targeted therapy. New techniques, such as next generation sequencing, allow tumour characterizations on the basis of DNA and/or RNA profiles. Moreover, the high sensitivity of digital PCR techniques enables DNA and RNA analysis on bodily fluids: the so called liquid biopsies. These developments will alter pathology practice dramatically in the coming years.

Original language	English
Title of host publication	Molecular Diagnostics
Subtitle of host publication	Part 2: Clinical, Veterinary, Agrobotanical and Food Safety Applications
Publisher	Springer Singapore
Pages	75-102
Number of pages	28
ISBN (Electronic)	9789811045110
ISBN (Print)	9789811045103
DOIs	https://doi.org/10.1007/978-981-10-4511-0_5
Publication status	Published - 19 Jul 2017

Keywords

Next generation sequencing
Pathology
Somatic mutation
Targeted therapy
Tumour

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10.1007/978-981-10-4511-0_5

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AU - Hinrichs, J. W.J.

AU - de Weger, R. A.

AU - van Blokland, W. T.M.

AU - Offerhaus, G. J.A.

AU - van Diest, P. J.

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AB - Molecular diagnostics is a rapidly growing discipline within pathology. This is largely explained by the changes in cancer treatment in the last decade. More and more types of cancer can be linked to specific DNA abnormalities and qualify for so-called targeted therapy. New techniques, such as next generation sequencing, allow tumour characterizations on the basis of DNA and/or RNA profiles. Moreover, the high sensitivity of digital PCR techniques enables DNA and RNA analysis on bodily fluids: the so called liquid biopsies. These developments will alter pathology practice dramatically in the coming years.

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KW - Pathology

KW - Somatic mutation

KW - Targeted therapy

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Molecular diagnostics in pathology

Abstract

Keywords

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