Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis

L. E. Hermans; J. J. Oosterheert; L. M. Kampschreur; J. Ossewaarde-Van Norel; J. Dekkers; A. Rothova; J. D F De Groot-Mijnes

doi:10.3109/09273948.2014.925123

Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis

L. E. Hermans, J. J. Oosterheert^*, L. M. Kampschreur, J. Ossewaarde-Van Norel, J. Dekkers, A. Rothova, J. D F De Groot-Mijnes

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: Previous studies have suggested a link between Q fever and uveitis. We determined whether Coxiella burnetii causes intraocular infection in C. burnetii-seropositive patients with idiopathic uveitis. Methods: From a retrospective observational case series, paired aqueous humor and serum samples from 10 C. burnetii-seropositive patients with idiopathic uveitis were examined for intraocular antibody production by using the Goldmann-Witmer coefficient and by polymerase chain reaction (PCR). Results: Although intraocular IgG against C. burnetii was detected, no intraocular antibody production was observed (low Goldmann Wittmer coefficients). All PCR results were negative. Conclusions: Uveitis due to an intraocular infection with C. burnetii is unlikely.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Ocular Immunology and Inflammation
Volume	24
Issue number	1
DOIs	https://doi.org/10.3109/09273948.2014.925123
Publication status	Published - 2 Jan 2016

Keywords

Aqueous humor analysis
Coxiella burnetii
infection
uveitis

Access to Document

10.3109/09273948.2014.925123

Cite this

Hermans, L. E., Oosterheert, J. J., Kampschreur, L. M., Ossewaarde-Van Norel, J., Dekkers, J., Rothova, A., & De Groot-Mijnes, J. D. F. (2016). Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis. Ocular Immunology and Inflammation, 24(1), 77-80. https://doi.org/10.3109/09273948.2014.925123

@article{a7b0e254486f40b69f0d106ef1a4ae33,

title = "Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis",

abstract = "Purpose: Previous studies have suggested a link between Q fever and uveitis. We determined whether Coxiella burnetii causes intraocular infection in C. burnetii-seropositive patients with idiopathic uveitis. Methods: From a retrospective observational case series, paired aqueous humor and serum samples from 10 C. burnetii-seropositive patients with idiopathic uveitis were examined for intraocular antibody production by using the Goldmann-Witmer coefficient and by polymerase chain reaction (PCR). Results: Although intraocular IgG against C. burnetii was detected, no intraocular antibody production was observed (low Goldmann Wittmer coefficients). All PCR results were negative. Conclusions: Uveitis due to an intraocular infection with C. burnetii is unlikely.",

keywords = "Aqueous humor analysis, Coxiella burnetii, infection, uveitis",

author = "Hermans, {L. E.} and Oosterheert, {J. J.} and Kampschreur, {L. M.} and {Ossewaarde-Van Norel}, J. and J. Dekkers and A. Rothova and {De Groot-Mijnes}, {J. D F}",

year = "2016",

month = jan,

day = "2",

doi = "10.3109/09273948.2014.925123",

language = "English",

volume = "24",

pages = "77--80",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis

AU - Hermans, L. E.

AU - Oosterheert, J. J.

AU - Kampschreur, L. M.

AU - Ossewaarde-Van Norel, J.

AU - Dekkers, J.

AU - Rothova, A.

AU - De Groot-Mijnes, J. D F

PY - 2016/1/2

Y1 - 2016/1/2

N2 - Purpose: Previous studies have suggested a link between Q fever and uveitis. We determined whether Coxiella burnetii causes intraocular infection in C. burnetii-seropositive patients with idiopathic uveitis. Methods: From a retrospective observational case series, paired aqueous humor and serum samples from 10 C. burnetii-seropositive patients with idiopathic uveitis were examined for intraocular antibody production by using the Goldmann-Witmer coefficient and by polymerase chain reaction (PCR). Results: Although intraocular IgG against C. burnetii was detected, no intraocular antibody production was observed (low Goldmann Wittmer coefficients). All PCR results were negative. Conclusions: Uveitis due to an intraocular infection with C. burnetii is unlikely.

AB - Purpose: Previous studies have suggested a link between Q fever and uveitis. We determined whether Coxiella burnetii causes intraocular infection in C. burnetii-seropositive patients with idiopathic uveitis. Methods: From a retrospective observational case series, paired aqueous humor and serum samples from 10 C. burnetii-seropositive patients with idiopathic uveitis were examined for intraocular antibody production by using the Goldmann-Witmer coefficient and by polymerase chain reaction (PCR). Results: Although intraocular IgG against C. burnetii was detected, no intraocular antibody production was observed (low Goldmann Wittmer coefficients). All PCR results were negative. Conclusions: Uveitis due to an intraocular infection with C. burnetii is unlikely.

KW - Aqueous humor analysis

KW - Coxiella burnetii

KW - infection

KW - uveitis

UR - http://www.scopus.com/inward/record.url?scp=84957942254&partnerID=8YFLogxK

U2 - 10.3109/09273948.2014.925123

DO - 10.3109/09273948.2014.925123

M3 - Article

C2 - 24945498

AN - SCOPUS:84957942254

SN - 0927-3948

VL - 24

SP - 77

EP - 80

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 1

ER -

Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this