Modeling specific aneuploidies: from karyotype manipulations to biological insights

My Anh Truong; Paula Cané-Gasull; Susanne M.A. Lens

doi:10.1007/s10577-023-09735-7

Modeling specific aneuploidies: from karyotype manipulations to biological insights

My Anh Truong, Paula Cané-Gasull, Susanne M.A. Lens^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

An abnormal chromosome number, or aneuploidy, underlies developmental disorders and is a common feature of cancer, with different cancer types exhibiting distinct patterns of chromosomal gains and losses. To understand how specific aneuploidies emerge in certain tissues and how they contribute to disease development, various methods have been developed to alter the karyotype of mammalian cells and mice. In this review, we provide an overview of both classic and novel strategies for inducing or selecting specific chromosomal gains and losses in human and murine cell systems. We highlight how these customized aneuploidy models helped expanding our knowledge of the consequences of specific aneuploidies to (cancer) cell physiology.

Original language	English
Article number	25
Number of pages	27
Journal	Chromosome Research
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s10577-023-09735-7
Publication status	Published - 29 Aug 2023

Keywords

Aneuploidy
cancer
chromosome
CIN
CRISPR/Cas9

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abstract = "An abnormal chromosome number, or aneuploidy, underlies developmental disorders and is a common feature of cancer, with different cancer types exhibiting distinct patterns of chromosomal gains and losses. To understand how specific aneuploidies emerge in certain tissues and how they contribute to disease development, various methods have been developed to alter the karyotype of mammalian cells and mice. In this review, we provide an overview of both classic and novel strategies for inducing or selecting specific chromosomal gains and losses in human and murine cell systems. We highlight how these customized aneuploidy models helped expanding our knowledge of the consequences of specific aneuploidies to (cancer) cell physiology.",

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AB - An abnormal chromosome number, or aneuploidy, underlies developmental disorders and is a common feature of cancer, with different cancer types exhibiting distinct patterns of chromosomal gains and losses. To understand how specific aneuploidies emerge in certain tissues and how they contribute to disease development, various methods have been developed to alter the karyotype of mammalian cells and mice. In this review, we provide an overview of both classic and novel strategies for inducing or selecting specific chromosomal gains and losses in human and murine cell systems. We highlight how these customized aneuploidy models helped expanding our knowledge of the consequences of specific aneuploidies to (cancer) cell physiology.

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Modeling specific aneuploidies: from karyotype manipulations to biological insights

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