Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F Boj; Chang-Il Hwang; Lindsey A Baker; Dannielle D Engle; David A Tuveson; Hans Clevers

doi:10.1080/23723556.2015.1014757

Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F Boj, Chang-Il Hwang, Lindsey A Baker, Dannielle D Engle, David A Tuveson, Hans Clevers

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Abstract

We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

Original language	English
Article number	e1014757
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1014757
Publication status	Published - Jan 2016

Keywords

cancer, pancreatic ductal adenocarcinoma, organoids, preclinical models

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title = "Model organoids provide new research opportunities for ductal pancreatic cancer",

abstract = "We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.",

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AU - Engle, Dannielle D

AU - Tuveson, David A

AU - Clevers, Hans

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AB - We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

KW - cancer, pancreatic ductal adenocarcinoma, organoids, preclinical models

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VL - 3

JO - Molecular and Cellular Oncology

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Model organoids provide new research opportunities for ductal pancreatic cancer

Abstract

Keywords

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