Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI

Hans Ligtenberg; Lisanne Jager; J Caldas Magalhaes; Tim Schakel; Frank A. Pameijer; Nicolien Kasperts; Stefan M. Willems; Chris H J Terhaard; CPJ Raaijmakers; Marielle E P Philippens

doi:10.1016/j.radonc.2017.02.005

Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI

Hans Ligtenberg^*, Lisanne Jager, J Caldas Magalhaes, Tim Schakel, Frank A. Pameijer, Nicolien Kasperts, Stefan M. Willems, Chris H J Terhaard, CPJ Raaijmakers, Marielle E P Philippens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and purpose: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. Material and methods: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumor_HE). The GTVs on CT and MRI were delineated in consensus. PET-based GTVs were automatically segmented. The three-dimensionally reconstructed specimen was registered to the various images. Modality-specific CTV margins were derived and added to the GTVs to achieve adequate tumor coverage. The resulting CTVs were compared with each other, to tumor_HE, and to CTV_CT10 constructed on CT with the clinical margin of 10mm. Results: CTV margins of 4.3mm (CT), 6.1mm (MRI) and 5.2mm (PET) were needed to achieve adequate tumor coverage. The median volumes of the resulting modality-specific CTVs were 44ml (CT), 48ml (MRI) and 39ml (PET), while the CTV_10mm was 80ml. Conclusion: For laryngohypopharyngeal tumors, 45-52% target volume reduction compared with CTV_10mm is achievable when modality-specific CTV margins are used. PET-based CTVs were significantly smaller compared to CT- and MRI-based CTVs.

Original language	English
Pages (from-to)	63-70
Number of pages	8
Journal	Radiotherapy & Oncology
Volume	123
Issue number	1
DOIs	https://doi.org/10.1016/j.radonc.2017.02.005
Publication status	Published - 2017

Keywords

CTV
GTV
Head and neck cancer
Imaging
Pathology

Access to Document

10.1016/j.radonc.2017.02.005

ModalityFinal published version, 1.55 MBLicence: CC BY-NC-ND

Cite this

@article{62ecd6745c4d40359d127afb4b6cd09c,

title = "Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI",

abstract = "Background and purpose: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. Material and methods: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus. PET-based GTVs were automatically segmented. The three-dimensionally reconstructed specimen was registered to the various images. Modality-specific CTV margins were derived and added to the GTVs to achieve adequate tumor coverage. The resulting CTVs were compared with each other, to tumorHE, and to CTVCT10 constructed on CT with the clinical margin of 10mm. Results: CTV margins of 4.3mm (CT), 6.1mm (MRI) and 5.2mm (PET) were needed to achieve adequate tumor coverage. The median volumes of the resulting modality-specific CTVs were 44ml (CT), 48ml (MRI) and 39ml (PET), while the CTV10mm was 80ml. Conclusion: For laryngohypopharyngeal tumors, 45-52% target volume reduction compared with CTV10mm is achievable when modality-specific CTV margins are used. PET-based CTVs were significantly smaller compared to CT- and MRI-based CTVs.",

keywords = "CTV, GTV, Head and neck cancer, Imaging, Pathology",

author = "Hans Ligtenberg and Lisanne Jager and {Caldas Magalhaes}, J and Tim Schakel and Pameijer, {Frank A.} and Nicolien Kasperts and Willems, {Stefan M.} and Terhaard, {Chris H J} and CPJ Raaijmakers and Philippens, {Marielle E P}",

note = "Funding Information: This work was supported by two research grants from the Dutch Cancer Society (UU 2011-5152 and UU 2011-5216). Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

doi = "10.1016/j.radonc.2017.02.005",

language = "English",

volume = "123",

pages = "63--70",

journal = "Radiotherapy & Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI

AU - Ligtenberg, Hans

AU - Jager, Lisanne

AU - Caldas Magalhaes, J

AU - Schakel, Tim

AU - Pameijer, Frank A.

AU - Kasperts, Nicolien

AU - Willems, Stefan M.

AU - Terhaard, Chris H J

AU - Raaijmakers, CPJ

AU - Philippens, Marielle E P

PY - 2017

Y1 - 2017

N2 - Background and purpose: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. Material and methods: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus. PET-based GTVs were automatically segmented. The three-dimensionally reconstructed specimen was registered to the various images. Modality-specific CTV margins were derived and added to the GTVs to achieve adequate tumor coverage. The resulting CTVs were compared with each other, to tumorHE, and to CTVCT10 constructed on CT with the clinical margin of 10mm. Results: CTV margins of 4.3mm (CT), 6.1mm (MRI) and 5.2mm (PET) were needed to achieve adequate tumor coverage. The median volumes of the resulting modality-specific CTVs were 44ml (CT), 48ml (MRI) and 39ml (PET), while the CTV10mm was 80ml. Conclusion: For laryngohypopharyngeal tumors, 45-52% target volume reduction compared with CTV10mm is achievable when modality-specific CTV margins are used. PET-based CTVs were significantly smaller compared to CT- and MRI-based CTVs.

AB - Background and purpose: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. Material and methods: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus. PET-based GTVs were automatically segmented. The three-dimensionally reconstructed specimen was registered to the various images. Modality-specific CTV margins were derived and added to the GTVs to achieve adequate tumor coverage. The resulting CTVs were compared with each other, to tumorHE, and to CTVCT10 constructed on CT with the clinical margin of 10mm. Results: CTV margins of 4.3mm (CT), 6.1mm (MRI) and 5.2mm (PET) were needed to achieve adequate tumor coverage. The median volumes of the resulting modality-specific CTVs were 44ml (CT), 48ml (MRI) and 39ml (PET), while the CTV10mm was 80ml. Conclusion: For laryngohypopharyngeal tumors, 45-52% target volume reduction compared with CTV10mm is achievable when modality-specific CTV margins are used. PET-based CTVs were significantly smaller compared to CT- and MRI-based CTVs.

KW - CTV

KW - GTV

KW - Head and neck cancer

KW - Imaging

KW - Pathology

UR - http://www.scopus.com/inward/record.url?scp=85014102766&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2017.02.005

DO - 10.1016/j.radonc.2017.02.005

M3 - Article

C2 - 28259450

AN - SCOPUS:85014102766

SN - 0167-8140

VL - 123

SP - 63

EP - 70

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

IS - 1

ER -

Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this