@article{ebd72fc9cd5b4ea49e950e010edfe4b6,
title = "miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury",
abstract = "Limited microRNAs (miRNAs, miRs) have been reported to be necessary for exercise-induced cardiac growth and essential for protection against pathological cardiac remodeling. Here we determined members of the miR-17-92 cluster and their passenger miRNAs expressions in two distinct murine exercise models and found that miR-17-3p was increased in both. miR-17-3p promoted cardiomyocyte hypertrophy, proliferation, and survival. TIMP-3 was identified as a direct target gene of miR-17-3p whereas PTEN was indirectly inhibited by miR-17-3p. Inhibition of miR-17-3p in vivo attenuated exercise-induced cardiac growth including cardiomyocyte hypertrophy and expression of markers of myocyte proliferation. Importantly, mice injected with miR-17-3p agomir were protected from adverse remodeling after cardiac ischemia/reperfusion injury. Collectively, these data suggest that miR-17-3p contributes to exercise-induced cardiac growth and protects against adverse ventricular remodeling. miR-17-3p may represent a novel therapeutic target to promote functional recovery after cardiac ischemia/reperfusion.",
keywords = "Cardiac growth, Exercise, microRNA",
author = "Jing Shi and Yihua Bei and Xiangqing Kong and Xiaojun Liu and Zhiyong Lei and Tianzhao Xu and Hui Wang and Qinkao Xuan and Ping Chen and Jiahong Xu and Lin Che and Hui Liu and Jiuchang Zhong and Sluijter, {Joost P.G.} and Xinli Li and Anthony Rosenzweig and Junjie Xiao",
note = "Funding Information: This work was supported by the grants from National Natural Science Foundation of China (81570362, 91639101, and 81200169 to JJ Xiao, 81370332 and 81170201 to XL Li, 81400647 to Y Bei, 81370362 to JC Zhong), NIH (R21HL114352, 1UH2TR000901, R01HL110733 to A Rosenzweig), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD20102013 to XL Li), the Netherlands Cardiovascular Research Initiative (CVON): the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organization for Health Research and Development, and the Royal Netherlands Academy of Science (to JPG Sluijter), the National Basic Research Program of China (2014CB542300), the National Major Research Plan Training Program (91339108), Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant (20152509). Dr XQ Kong is a Fellow and Dr XL Li is an Associate Fellow at the Collaborative Innovation Center For Cardiovascular Disease Translational Medicine. Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",
year = "2017",
doi = "10.7150/thno.15162",
language = "English",
volume = "7",
pages = "664--676",
number = "3",
}