TY - JOUR
T1 - Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use
T2 - A Systematic Review
AU - Grubliauskaite, Monika
AU - van der Perk, M E Madeleine
AU - Bos, Annelies M E
AU - Meijer, Annelot J M
AU - Gudleviciene, Zivile
AU - van den Heuvel-Eibrink, Marry M
AU - Rascon, Jelena
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/9
Y1 - 2023/9
N2 - BACKGROUND: Ovarian tissue cryopreservation and transplantation are the only available fertility techniques for prepubertal girls with cancer. Though autotransplantation carries a risk of reintroducing malignant cells, it can be avoided by identifying minimal infiltrative disease (MID) within ovarian tissue.METHODS: A broad search for peer-reviewed articles in the PubMed database was conducted in accordance with PRISMA guidelines up to March 2023. Search terms included 'minimal residual disease', 'cryopreservation', 'ovarian', 'cancer' and synonyms.RESULTS: Out of 542 identified records, 17 were included. Ovarian tissues of at least 115 girls were evaluated and categorized as: hematological malignancies (
n = 56; 48.7%), solid tumors (
n = 42; 36.5%) and tumors of the central nervous system (
n = 17; 14.8%). In ovarian tissue of 25 patients (21.7%), MID was detected using RT-qPCR, FISH or multicolor flow cytometry: 16 of them (64%) being ALL (
IgH rearrangements with/without
TRG,
BCL-ABL1,
EA2-PBX1,
TEL-AML1 fusion transcripts), 3 (12%) Ewing sarcoma (
EWS-FLI1 fusion transcript,
EWSR1 rearrangements), 3 (12%) CML (
BCR-ABL1 fusion transcript,
FLT3) and 3 (12%) AML (leukemia-associated immunophenotypes,
BCR-ABL1 fusion transcript) patients.
CONCLUSION: While the majority of malignancies were found to have a low risk of containing malignant cells in ovarian tissue, further studies are needed to ensure safe implementation of future fertility restoration in clinical practice.
AB - BACKGROUND: Ovarian tissue cryopreservation and transplantation are the only available fertility techniques for prepubertal girls with cancer. Though autotransplantation carries a risk of reintroducing malignant cells, it can be avoided by identifying minimal infiltrative disease (MID) within ovarian tissue.METHODS: A broad search for peer-reviewed articles in the PubMed database was conducted in accordance with PRISMA guidelines up to March 2023. Search terms included 'minimal residual disease', 'cryopreservation', 'ovarian', 'cancer' and synonyms.RESULTS: Out of 542 identified records, 17 were included. Ovarian tissues of at least 115 girls were evaluated and categorized as: hematological malignancies (
n = 56; 48.7%), solid tumors (
n = 42; 36.5%) and tumors of the central nervous system (
n = 17; 14.8%). In ovarian tissue of 25 patients (21.7%), MID was detected using RT-qPCR, FISH or multicolor flow cytometry: 16 of them (64%) being ALL (
IgH rearrangements with/without
TRG,
BCL-ABL1,
EA2-PBX1,
TEL-AML1 fusion transcripts), 3 (12%) Ewing sarcoma (
EWS-FLI1 fusion transcript,
EWSR1 rearrangements), 3 (12%) CML (
BCR-ABL1 fusion transcript,
FLT3) and 3 (12%) AML (leukemia-associated immunophenotypes,
BCR-ABL1 fusion transcript) patients.
CONCLUSION: While the majority of malignancies were found to have a low risk of containing malignant cells in ovarian tissue, further studies are needed to ensure safe implementation of future fertility restoration in clinical practice.
KW - cancer survivors
KW - cryopreservation
KW - fertility restoration
KW - minimal infiltrative disease
KW - minimally residual disease
KW - ovarian tissue
KW - pediatric patients
UR - https://www.scopus.com/pages/publications/85170383682
U2 - 10.3390/cancers15174199
DO - 10.3390/cancers15174199
M3 - Review article
C2 - 37686475
SN - 2072-6694
VL - 15
SP - 1
EP - 26
JO - Cancers
JF - Cancers
IS - 17
M1 - 4199
ER -