MicroRNAs: Role and therapeutic targets in viral hepatitis Meike H van der Ree

Meike H.Der Van Ree; Joep De Bruijne; Neeltje A. Kootstra; Peter L.M. Jansen; Hendrik W. Reesink

doi:10.3851/IMP2766

MicroRNAs: Role and therapeutic targets in viral hepatitis Meike H van der Ree

Meike H.Der Van Ree, Joep De Bruijne, Neeltje A. Kootstra, Peter L.M. Jansen, Hendrik W. Reesink

Research output: Contribution to journal › Review article › peer-review

Abstract

MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. Micro-RNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis.

Original language	English
Pages (from-to)	533-541
Number of pages	9
Journal	Antiviral Therapy
Volume	19
Issue number	6
DOIs	https://doi.org/10.3851/IMP2766
Publication status	Published - 2014
Externally published	Yes

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title = "MicroRNAs: Role and therapeutic targets in viral hepatitis Meike H van der Ree",

abstract = "MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. Micro-RNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis.",

author = "{Van Ree}, {Meike H.Der} and {De Bruijne}, Joep and Kootstra, {Neeltje A.} and Jansen, {Peter L.M.} and Reesink, {Hendrik W.}",

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year = "2014",

doi = "10.3851/IMP2766",

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journal = "Antiviral Therapy",

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T1 - MicroRNAs

T2 - Role and therapeutic targets in viral hepatitis Meike H van der Ree

AU - Van Ree, Meike H.Der

AU - De Bruijne, Joep

AU - Kootstra, Neeltje A.

AU - Jansen, Peter L.M.

AU - Reesink, Hendrik W.

PY - 2014

Y1 - 2014

N2 - MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. Micro-RNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis.

AB - MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. Micro-RNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis.

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MicroRNAs: Role and therapeutic targets in viral hepatitis Meike H van der Ree

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