MicroRNAs: Role and therapeutic targets in viral hepatitis Meike H van der Ree

Meike H.Der Van Ree, Joep De Bruijne, Neeltje A. Kootstra, Peter L.M. Jansen, Hendrik W. Reesink

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. Micro-RNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis.

Original languageEnglish
Pages (from-to)533-541
Number of pages9
JournalAntiviral Therapy
Volume19
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

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