Abstract
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 23-fold higher in patients with ONFH compared to patients without ONFH, and 25-fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of ONFH in SCD. Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of ONFH in SCD.
Original language | English |
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Pages (from-to) | 135-138 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 168 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2015 |
Keywords
- anaemia
- sickle cell disease
- coagulation
- clinical haematology
- haemoglobinopathies
- FEMORAL-HEAD
- LYSOPHOSPHATIDIC ACID
- PHOSPHATIDYLSERINE
- ANEMIA