Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease

Anne Marsh*, Raymond Schiffelers, Frans Kuypers, Sandra Larkin, Ginny Gildengorin, Wouter van Solinge, Carolyn Hoppe

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 23-fold higher in patients with ONFH compared to patients without ONFH, and 25-fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of ONFH in SCD. Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of ONFH in SCD.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalBritish Journal of Haematology
Volume168
Issue number1
DOIs
Publication statusPublished - Jan 2015

Keywords

  • anaemia
  • sickle cell disease
  • coagulation
  • clinical haematology
  • haemoglobinopathies
  • FEMORAL-HEAD
  • LYSOPHOSPHATIDIC ACID
  • PHOSPHATIDYLSERINE
  • ANEMIA

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