TY - JOUR
T1 - Microcarriers in the engineering of cartilage and bone
AU - Malda, Jos
AU - Frondoza, Carmelita G.
PY - 2006/7/1
Y1 - 2006/7/1
N2 - A major problem in tissue engineering is the availability of a sufficient number of cells with the appropriate phenotype for delivery to damaged or diseased cartilage and bone; the challenge is to amplify cell numbers and maintain the appropriate phenotype for tissue repair and restoration of function. The microcarrier bioreactor culture system offers an attractive method for cell amplification and enhancement of phenotype expression. Besides serving as substrates for the propagation of anchorage-dependent cells, microcarriers can also be used to deliver the expanded undifferentiated or differentiated cells to the site of the defect. The present article provides an overview of the microcarrier culture system, its utility as an in vitro research tool and its potential applications in tissue engineering, particularly in the repair of cartilage and bone. Crown
AB - A major problem in tissue engineering is the availability of a sufficient number of cells with the appropriate phenotype for delivery to damaged or diseased cartilage and bone; the challenge is to amplify cell numbers and maintain the appropriate phenotype for tissue repair and restoration of function. The microcarrier bioreactor culture system offers an attractive method for cell amplification and enhancement of phenotype expression. Besides serving as substrates for the propagation of anchorage-dependent cells, microcarriers can also be used to deliver the expanded undifferentiated or differentiated cells to the site of the defect. The present article provides an overview of the microcarrier culture system, its utility as an in vitro research tool and its potential applications in tissue engineering, particularly in the repair of cartilage and bone. Crown
UR - http://www.scopus.com/inward/record.url?scp=33745575077&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2006.04.009
DO - 10.1016/j.tibtech.2006.04.009
M3 - Review article
C2 - 16678291
AN - SCOPUS:33745575077
SN - 0167-7799
VL - 24
SP - 299
EP - 304
JO - Trends in biotechnology
JF - Trends in biotechnology
IS - 7
ER -