TY - JOUR
T1 - Microbleeds on MRI are associated with microinfarcts on autopsy in cerebral amyloid angiopathy
AU - Lauer, Arne
AU - Van Veluw, Susanne J.
AU - William, Christopher M.
AU - Charidimou, Andreas
AU - Roongpiboonsopit, Duangnapa
AU - Vashkevich, Anastasia
AU - Ayres, Alison
AU - Martinez-Ramirez, Sergi
AU - Gurol, Edip M.
AU - Biessels, Geert Jan
AU - Frosch, Matthew
AU - Greenberg, Steven M.
AU - Viswanathan, Anand
PY - 2016/10/4
Y1 - 2016/10/4
N2 - OBJECTIVES: To identify in vivo MRI markers that might correlate with cerebral microinfarcts (CMIs) on autopsy in patients with cerebral amyloid angiopathy (CAA).METHODS: We included patients with neuropathologic evidence of CAA on autopsy and available antemortem brain MRI. Clinical characteristics and in vivo MRI markers of CAA-related small vessel disease were recorded, including white matter hyperintensities, cerebral microbleeds, cortical superficial siderosis, and centrum semiovale perivascular spaces. In addition, the presence of intracerebral hemorrhage on MRI was assessed. Evaluation of the presence and number of CMIs was performed in 9 standard histology sections.RESULTS: Of 49 analyzed patients with CAA, CMIs were present in 36.7%. The presence of ≥1 CMIs on autopsy was associated with higher numbers of microbleeds on antemortem MRI (median 8 [interquartile range 2.5-33.0] vs 1 [interquartile range 0-3], p = 0.003) and with the presence of intracerebral hemorrhage (44.4% vs 16.1%, p = 0.03). No associations between CMIs and other in vivo MRI markers of CAA were found. In a multivariable model adjusted for severe CAA pathology, higher numbers of microbleeds were independent predictors of the presence of CMIs on pathology.CONCLUSIONS: CMIs are a common finding at autopsy in patients with CAA. The strong association between MRI-observed microbleeds and CMIs at autopsy may suggest a shared underlying pathophysiologic mechanism between these lesions.
AB - OBJECTIVES: To identify in vivo MRI markers that might correlate with cerebral microinfarcts (CMIs) on autopsy in patients with cerebral amyloid angiopathy (CAA).METHODS: We included patients with neuropathologic evidence of CAA on autopsy and available antemortem brain MRI. Clinical characteristics and in vivo MRI markers of CAA-related small vessel disease were recorded, including white matter hyperintensities, cerebral microbleeds, cortical superficial siderosis, and centrum semiovale perivascular spaces. In addition, the presence of intracerebral hemorrhage on MRI was assessed. Evaluation of the presence and number of CMIs was performed in 9 standard histology sections.RESULTS: Of 49 analyzed patients with CAA, CMIs were present in 36.7%. The presence of ≥1 CMIs on autopsy was associated with higher numbers of microbleeds on antemortem MRI (median 8 [interquartile range 2.5-33.0] vs 1 [interquartile range 0-3], p = 0.003) and with the presence of intracerebral hemorrhage (44.4% vs 16.1%, p = 0.03). No associations between CMIs and other in vivo MRI markers of CAA were found. In a multivariable model adjusted for severe CAA pathology, higher numbers of microbleeds were independent predictors of the presence of CMIs on pathology.CONCLUSIONS: CMIs are a common finding at autopsy in patients with CAA. The strong association between MRI-observed microbleeds and CMIs at autopsy may suggest a shared underlying pathophysiologic mechanism between these lesions.
UR - http://www.scopus.com/inward/record.url?scp=84989844347&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000003184
DO - 10.1212/WNL.0000000000003184
M3 - Article
C2 - 27613583
AN - SCOPUS:84989844347
SN - 0028-3878
VL - 87
SP - 1488
EP - 1492
JO - Neurology
JF - Neurology
IS - 14
ER -