Microarray techniques in pathology: tool or toy?

A M Snijders; G A Meijer; R H Brakenhoff; A J van den Brule; P J van Diest

Microarray techniques in pathology: tool or toy?

A M Snijders
, G A Meijer
, R H Brakenhoff
, A J van den Brule
, P J van Diest

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical "ins and outs" of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

Original language	English
Pages (from-to)	289-94
Number of pages	6
Journal	Molecular Pathology : MP
Volume	53
Issue number	6
Publication status	Published - Dec 2000

Keywords

DNA Mutational Analysis
Gene Expression Profiling
Humans
Neoplasms
Nucleic Acid Hybridization
Oligonucleotide Array Sequence Analysis

Cite this

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title = "Microarray techniques in pathology: tool or toy?",

abstract = "Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical {"}ins and outs{"} of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.",

keywords = "DNA Mutational Analysis, Gene Expression Profiling, Humans, Neoplasms, Nucleic Acid Hybridization, Oligonucleotide Array Sequence Analysis",

author = "Snijders, \{A M\} and Meijer, \{G A\} and Brakenhoff, \{R H\} and \{van den Brule\}, \{A J\} and \{van Diest\}, \{P J\}",

year = "2000",

month = dec,

language = "English",

volume = "53",

pages = "289--94",

journal = "Molecular Pathology : MP",

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T1 - Microarray techniques in pathology

T2 - tool or toy?

AU - Snijders, A M

AU - Meijer, G A

AU - Brakenhoff, R H

AU - van den Brule, A J

AU - van Diest, P J

PY - 2000/12

Y1 - 2000/12

N2 - Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical "ins and outs" of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

AB - Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical "ins and outs" of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

KW - DNA Mutational Analysis

KW - Gene Expression Profiling

KW - Humans

KW - Neoplasms

KW - Nucleic Acid Hybridization

KW - Oligonucleotide Array Sequence Analysis

M3 - Article

C2 - 11193046

SN - 1366-8714

VL - 53

SP - 289

EP - 294

JO - Molecular Pathology : MP

JF - Molecular Pathology : MP

IS - 6

ER -

Microarray techniques in pathology: tool or toy?

Abstract

Keywords

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