Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients: A Pilot Study

AP de Ruiter; Nard Janssen; Robert van Es; Michael Frank; Gert Meijer; Ron Koole; Toine Rosenberg

doi:10.1597/13-260

Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients: A Pilot Study

AP de Ruiter, Nard Janssen, Robert van Es, Michael Frank, Gert Meijer, Ron Koole, Toine Rosenberg

Dept of Surgical Oncology - head & neck

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (β-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation.

DESIGN: Prospective clinical study.

SETTING: University clinic.

PARTICIPANTS: Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with β-TCP in 2010 and 2011.

MAIN OUTCOME MEASURES: In all patients, the alveolar cleft was repaired by micro-structured β-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized.

RESULTS: Six months after the operative grafting of micro-structured β-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% ± 6% compared with the original cleft volume.

CONCLUSIONS: Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured β-TCP bone substitute for repair of the alveolar cleft.

Original language	English
Pages (from-to)	336-340
Number of pages	5
Journal	Cleft Palate-Craniofacial Journal
Volume	52
Issue number	3
DOIs	https://doi.org/10.1597/13-260
Publication status	Published - 2015

Keywords

β-TCP
bone grafting
bone regeneration
bone substitute
cleft lip and palate (CLP)

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title = "Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients: A Pilot Study",

abstract = "OBJECTIVES: Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (β-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation.DESIGN: Prospective clinical study.SETTING: University clinic.PARTICIPANTS: Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with β-TCP in 2010 and 2011.MAIN OUTCOME MEASURES: In all patients, the alveolar cleft was repaired by micro-structured β-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized.RESULTS: Six months after the operative grafting of micro-structured β-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% ± 6% compared with the original cleft volume.CONCLUSIONS: Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured β-TCP bone substitute for repair of the alveolar cleft.",

keywords = "β-TCP, bone grafting, bone regeneration, bone substitute, cleft lip and palate (CLP)",

author = "{de Ruiter}, AP and Nard Janssen and {van Es}, Robert and Michael Frank and Gert Meijer and Ron Koole and Toine Rosenberg",

year = "2015",

doi = "10.1597/13-260",

language = "English",

volume = "52",

pages = "336--340",

journal = "Cleft Palate-Craniofacial Journal",

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publisher = "American Cleft Palate Craniofacial Association",

number = "3",

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TY - JOUR

T1 - Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients

T2 - A Pilot Study

AU - de Ruiter, AP

AU - Janssen, Nard

AU - van Es, Robert

AU - Frank, Michael

AU - Meijer, Gert

AU - Koole, Ron

AU - Rosenberg, Toine

PY - 2015

Y1 - 2015

N2 - OBJECTIVES: Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (β-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation.DESIGN: Prospective clinical study.SETTING: University clinic.PARTICIPANTS: Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with β-TCP in 2010 and 2011.MAIN OUTCOME MEASURES: In all patients, the alveolar cleft was repaired by micro-structured β-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized.RESULTS: Six months after the operative grafting of micro-structured β-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% ± 6% compared with the original cleft volume.CONCLUSIONS: Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured β-TCP bone substitute for repair of the alveolar cleft.

AB - OBJECTIVES: Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (β-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation.DESIGN: Prospective clinical study.SETTING: University clinic.PARTICIPANTS: Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with β-TCP in 2010 and 2011.MAIN OUTCOME MEASURES: In all patients, the alveolar cleft was repaired by micro-structured β-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized.RESULTS: Six months after the operative grafting of micro-structured β-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% ± 6% compared with the original cleft volume.CONCLUSIONS: Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured β-TCP bone substitute for repair of the alveolar cleft.

KW - β-TCP

KW - bone grafting

KW - bone regeneration

KW - bone substitute

KW - cleft lip and palate (CLP)

U2 - 10.1597/13-260

DO - 10.1597/13-260

M3 - Article

C2 - 24919123

SN - 1055-6656

VL - 52

SP - 336

EP - 340

JO - Cleft Palate-Craniofacial Journal

JF - Cleft Palate-Craniofacial Journal

IS - 3

ER -

Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients: A Pilot Study

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Keywords

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