MHC class I chain-related gene A diversity in head and neck squamous cell carcinoma

J. Reinders; E.H. Rozemuller; K. van der Ven; S. Caillat-Zucman; P.J. Slootweg; R.A. de Weger; M.G.J. Tilanus

doi:10.1016/j.humimm.2006.02.006

MHC class I chain-related gene A diversity in head and neck squamous cell carcinoma

J. Reinders, E.H. Rozemuller, K. van der Ven, S. Caillat-Zucman, P.J. Slootweg, R.A. de Weger, M.G.J. Tilanus

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Many immune-related genes are located within the human leukocyte antigen (HLA) region on chromosome 6. The MHC class I chain-related gene A (MICA), located centromeric of HLA-B, is involved in the innate and adaptive immune response through activation of NK and T cells. Differences of MICA transmembrane repeat lengths have been associated with diseases and expression is observed on epithelial tumors. Head and neck squamous cell carcinoma (HNSCC) is an epithelial tumor. In the present study we evaluated the MICA repeat length diversity in relation to MICA expression in Dutch HNSCC patients. MICA short tandem repeat analysis indicated a significant decrease in the frequency for the MICA-A9 repeat in patients diagnosed with oral cavity squamous cell carcinoma (SCC) but not in patients with SCC in the hypoharynx, larynx, or oropharynx. Interestingly, the majority of patients expressed MICA as observed with immunohistochemical staining whereas no soluble MICA was detected in patients' sera by enzyme-linked immunosorbent assay. In conclusion, the length of the MICA transmembrane repeats in Dutch HNSCC patients does not influence the MICA expression on tumor cells.

Original language	English
Pages (from-to)	196-203
Number of pages	8
Journal	Human Immunology
Volume	67
Issue number	3
DOIs	https://doi.org/10.1016/j.humimm.2006.02.006
Publication status	Published - Mar 2006

Keywords

HLA
MICA repeat
MICA expression
HNSCC
MAJOR HISTOCOMPATIBILITY COMPLEX
TRIPLET REPEAT POLYMORPHISM
MICA GENE
NASOPHARYNGEAL CARCINOMA
TRANSMEMBRANE REGION
T-CELLS
ASSOCIATION
SUSCEPTIBILITY
EXPRESSION

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10.1016/j.humimm.2006.02.006

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@article{22908dd25eb04b49aa2bb9d2d0deb450,

title = "MHC class I chain-related gene A diversity in head and neck squamous cell carcinoma",

abstract = "Many immune-related genes are located within the human leukocyte antigen (HLA) region on chromosome 6. The MHC class I chain-related gene A (MICA), located centromeric of HLA-B, is involved in the innate and adaptive immune response through activation of NK and T cells. Differences of MICA transmembrane repeat lengths have been associated with diseases and expression is observed on epithelial tumors. Head and neck squamous cell carcinoma (HNSCC) is an epithelial tumor. In the present study we evaluated the MICA repeat length diversity in relation to MICA expression in Dutch HNSCC patients. MICA short tandem repeat analysis indicated a significant decrease in the frequency for the MICA-A9 repeat in patients diagnosed with oral cavity squamous cell carcinoma (SCC) but not in patients with SCC in the hypoharynx, larynx, or oropharynx. Interestingly, the majority of patients expressed MICA as observed with immunohistochemical staining whereas no soluble MICA was detected in patients' sera by enzyme-linked immunosorbent assay. In conclusion, the length of the MICA transmembrane repeats in Dutch HNSCC patients does not influence the MICA expression on tumor cells.",

keywords = "HLA, MICA repeat, MICA expression, HNSCC, MAJOR HISTOCOMPATIBILITY COMPLEX, TRIPLET REPEAT POLYMORPHISM, MICA GENE, NASOPHARYNGEAL CARCINOMA, TRANSMEMBRANE REGION, T-CELLS, ASSOCIATION, SUSCEPTIBILITY, EXPRESSION",

author = "J. Reinders and E.H. Rozemuller and {van der Ven}, K. and S. Caillat-Zucman and P.J. Slootweg and {de Weger}, R.A. and M.G.J. Tilanus",

year = "2006",

month = mar,

doi = "10.1016/j.humimm.2006.02.006",

language = "English",

volume = "67",

pages = "196--203",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier",

number = "3",

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TY - JOUR

T1 - MHC class I chain-related gene A diversity in head and neck squamous cell carcinoma

AU - Reinders, J.

AU - Rozemuller, E.H.

AU - van der Ven, K.

AU - Caillat-Zucman, S.

AU - Slootweg, P.J.

AU - de Weger, R.A.

AU - Tilanus, M.G.J.

PY - 2006/3

Y1 - 2006/3

N2 - Many immune-related genes are located within the human leukocyte antigen (HLA) region on chromosome 6. The MHC class I chain-related gene A (MICA), located centromeric of HLA-B, is involved in the innate and adaptive immune response through activation of NK and T cells. Differences of MICA transmembrane repeat lengths have been associated with diseases and expression is observed on epithelial tumors. Head and neck squamous cell carcinoma (HNSCC) is an epithelial tumor. In the present study we evaluated the MICA repeat length diversity in relation to MICA expression in Dutch HNSCC patients. MICA short tandem repeat analysis indicated a significant decrease in the frequency for the MICA-A9 repeat in patients diagnosed with oral cavity squamous cell carcinoma (SCC) but not in patients with SCC in the hypoharynx, larynx, or oropharynx. Interestingly, the majority of patients expressed MICA as observed with immunohistochemical staining whereas no soluble MICA was detected in patients' sera by enzyme-linked immunosorbent assay. In conclusion, the length of the MICA transmembrane repeats in Dutch HNSCC patients does not influence the MICA expression on tumor cells.

AB - Many immune-related genes are located within the human leukocyte antigen (HLA) region on chromosome 6. The MHC class I chain-related gene A (MICA), located centromeric of HLA-B, is involved in the innate and adaptive immune response through activation of NK and T cells. Differences of MICA transmembrane repeat lengths have been associated with diseases and expression is observed on epithelial tumors. Head and neck squamous cell carcinoma (HNSCC) is an epithelial tumor. In the present study we evaluated the MICA repeat length diversity in relation to MICA expression in Dutch HNSCC patients. MICA short tandem repeat analysis indicated a significant decrease in the frequency for the MICA-A9 repeat in patients diagnosed with oral cavity squamous cell carcinoma (SCC) but not in patients with SCC in the hypoharynx, larynx, or oropharynx. Interestingly, the majority of patients expressed MICA as observed with immunohistochemical staining whereas no soluble MICA was detected in patients' sera by enzyme-linked immunosorbent assay. In conclusion, the length of the MICA transmembrane repeats in Dutch HNSCC patients does not influence the MICA expression on tumor cells.

KW - HLA

KW - MICA repeat

KW - MICA expression

KW - HNSCC

KW - MAJOR HISTOCOMPATIBILITY COMPLEX

KW - TRIPLET REPEAT POLYMORPHISM

KW - MICA GENE

KW - NASOPHARYNGEAL CARCINOMA

KW - TRANSMEMBRANE REGION

KW - T-CELLS

KW - ASSOCIATION

KW - SUSCEPTIBILITY

KW - EXPRESSION

U2 - 10.1016/j.humimm.2006.02.006

DO - 10.1016/j.humimm.2006.02.006

M3 - Article

C2 - 16698442

SN - 0198-8859

VL - 67

SP - 196

EP - 203

JO - Human Immunology

JF - Human Immunology

IS - 3

ER -

MHC class I chain-related gene A diversity in head and neck squamous cell carcinoma

Abstract

Keywords

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