TY - JOUR
T1 - Methodologies of Neuroepigenetic Research
T2 - Background, Challenges and Future Perspectives
AU - Snijders, Clara
AU - Bassil, Katherine C
AU - de Nijs, Laurence
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Over the last years, interest in epigenetic mechanisms has strongly increased in the field of neuroscience. Neuroepigenetics has intensely evolved and now refers to the assessment of a variety of epigenetic marks which can be found across several regions of the healthy or diseased brain. These marks include DNA (hydroxy)methylation, a large diversity of post-translational histone modifications and an increasing number of non-coding RNAs. The present chapter aims to concisely summarize the techniques used to study these mechanisms in the brain and provides an overview of their current challenges along with future perspectives that will allow the field to move forward.
AB - Over the last years, interest in epigenetic mechanisms has strongly increased in the field of neuroscience. Neuroepigenetics has intensely evolved and now refers to the assessment of a variety of epigenetic marks which can be found across several regions of the healthy or diseased brain. These marks include DNA (hydroxy)methylation, a large diversity of post-translational histone modifications and an increasing number of non-coding RNAs. The present chapter aims to concisely summarize the techniques used to study these mechanisms in the brain and provides an overview of their current challenges along with future perspectives that will allow the field to move forward.
KW - DNA Methylation/genetics
KW - Epigenesis, Genetic
KW - Humans
KW - Nervous System/metabolism
KW - Organ Specificity/genetics
KW - Research Design
UR - http://www.scopus.com/inward/record.url?scp=85048585217&partnerID=8YFLogxK
U2 - 10.1016/bs.pmbts.2018.04.009
DO - 10.1016/bs.pmbts.2018.04.009
M3 - Review article
C2 - 30072052
SN - 1877-1173
VL - 158
SP - 15
EP - 27
JO - Progress in molecular biology and translational science
JF - Progress in molecular biology and translational science
ER -