Methodological Advances in Ultra-high Field Metabolic MRI in Cancer

Z Shams

doi:10.33540/2367

Methodological Advances in Ultra-high Field Metabolic MRI in Cancer

Z Shams

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

The primary objective of this thesis was to develop and refine a range of proton (1H) MRS, 31P-MRSI, and 23Na-MRI methods at 7T for application in studies on brain tumors. The work in this thesis focuses on implementation of different MRS sequences with the purpose of IDH-mutated glioma characterization at 7T with 1H-MRS, development of 31P-MRSI with the aim of increasing SNR per unit of time while requiring low power, and assessment of the practicality and feasibility of interleaving 23Na-MRI and 31P-MRSI acquisitions to enable full metabolic characterization of the brain in one single scan within one scan session.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Klomp, Dennis, Primary supervisor Wijnen, Jannie, Co-supervisor Wiegers, Evita, Co-supervisor
Award date	7 Jan 2025
Publisher	Utrecht University
Print ISBNs	978-90-834947-4-6
DOIs	https://doi.org/10.33540/2367
Publication status	Published - 7 Jan 2025

Keywords

1H-MRS
oncometabolite 2HG
31P-MRSI
Ultra-high field
interleaved MR acquisitions
x-nuclei

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10.33540/2367

dissertationzahrashams - 676079d77290dFinal published version, 15.7 MB

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title = "Methodological Advances in Ultra-high Field Metabolic MRI in Cancer",

abstract = "The primary objective of this thesis was to develop and refine a range of proton (1H) MRS, 31P-MRSI, and 23Na-MRI methods at 7T for application in studies on brain tumors. The work in this thesis focuses on implementation of different MRS sequences with the purpose of IDH-mutated glioma characterization at 7T with 1H-MRS, development of 31P-MRSI with the aim of increasing SNR per unit of time while requiring low power, and assessment of the practicality and feasibility of interleaving 23Na-MRI and 31P-MRSI acquisitions to enable full metabolic characterization of the brain in one single scan within one scan session.",

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language = "English",

isbn = "978-90-834947-4-6",

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type = "Doctoral thesis 1 (Research UU / Graduation UU)",

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N2 - The primary objective of this thesis was to develop and refine a range of proton (1H) MRS, 31P-MRSI, and 23Na-MRI methods at 7T for application in studies on brain tumors. The work in this thesis focuses on implementation of different MRS sequences with the purpose of IDH-mutated glioma characterization at 7T with 1H-MRS, development of 31P-MRSI with the aim of increasing SNR per unit of time while requiring low power, and assessment of the practicality and feasibility of interleaving 23Na-MRI and 31P-MRSI acquisitions to enable full metabolic characterization of the brain in one single scan within one scan session.

AB - The primary objective of this thesis was to develop and refine a range of proton (1H) MRS, 31P-MRSI, and 23Na-MRI methods at 7T for application in studies on brain tumors. The work in this thesis focuses on implementation of different MRS sequences with the purpose of IDH-mutated glioma characterization at 7T with 1H-MRS, development of 31P-MRSI with the aim of increasing SNR per unit of time while requiring low power, and assessment of the practicality and feasibility of interleaving 23Na-MRI and 31P-MRSI acquisitions to enable full metabolic characterization of the brain in one single scan within one scan session.

KW - 1H-MRS

KW - oncometabolite 2HG

KW - 31P-MRSI

KW - Ultra-high field

KW - interleaved MR acquisitions

KW - x-nuclei

U2 - 10.33540/2367

DO - 10.33540/2367

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-90-834947-4-6

PB - Utrecht University

ER -

Methodological Advances in Ultra-high Field Metabolic MRI in Cancer

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Keywords

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