Methodological Advances in Ultra-high Field Metabolic MRI in Cancer

Z Shams

Research output: ThesisDoctoral thesis 1 (Research UU / Graduation UU)

2 Downloads (Pure)

Abstract

The primary objective of this thesis was to develop and refine a range of proton (1H) MRS, 31P-MRSI, and 23Na-MRI methods at 7T for application in studies on brain tumors. The work in this thesis focuses on implementation of different MRS sequences with the purpose of IDH-mutated glioma characterization at 7T with 1H-MRS, development of 31P-MRSI with the aim of increasing SNR per unit of time while requiring low power, and assessment of the practicality and feasibility of interleaving 23Na-MRI and 31P-MRSI acquisitions to enable full metabolic characterization of the brain in one single scan within one scan session.
Original languageEnglish
Awarding Institution
  • University Medical Center (UMC) Utrecht
Supervisors/Advisors
  • Klomp, Dennis, Primary supervisor
  • Wijnen, Jannie, Co-supervisor
  • Wiegers, Evita, Co-supervisor
Award date7 Jan 2025
Publisher
Print ISBNs978-90-834947-4-6
DOIs
Publication statusPublished - 7 Jan 2025

Keywords

  • 1H-MRS
  • oncometabolite 2HG
  • 31P-MRSI
  • Ultra-high field
  • interleaved MR acquisitions
  • x-nuclei

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