Abstract
The primary objective of this thesis was to develop and refine a range of proton (1H) MRS, 31P-MRSI, and 23Na-MRI methods at 7T for application in studies on brain tumors. The work in this thesis focuses on implementation of different MRS sequences with the purpose of IDH-mutated glioma characterization at 7T with 1H-MRS, development of 31P-MRSI with the aim of increasing SNR per unit of time while requiring low power, and assessment of the practicality and feasibility of interleaving 23Na-MRI and 31P-MRSI acquisitions to enable full metabolic characterization of the brain in one single scan within one scan session.
Original language | English |
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Award date | 7 Jan 2025 |
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Print ISBNs | 978-90-834947-4-6 |
DOIs | |
Publication status | Published - 7 Jan 2025 |
Keywords
- 1H-MRS
- oncometabolite 2HG
- 31P-MRSI
- Ultra-high field
- interleaved MR acquisitions
- x-nuclei