Metformin-associated lactic acidosis in a patient with normal kidney function

T T van Sloten; E Pijpers; C D A Stehouwer; M C G J Brouwers

doi:10.1016/j.diabres.2011.07.021

Metformin-associated lactic acidosis in a patient with normal kidney function

T T van Sloten
, E Pijpers
, C D A Stehouwer
, M C G J Brouwers

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The existence of metformin-induced lactic acidosis has been questioned, in particular in the absence of specific risk factors such as impaired renal function. This report describes the presence of lactic acidosis in a patient with normal kidney function and normal doses of metformin. Subsequent positive rechallenge with metformin confirms causality.

Original language	English
Pages (from-to)	e57-58
Journal	Diabetes Research and Clinical Practice
Volume	96
Issue number	3
DOIs	https://doi.org/10.1016/j.diabres.2011.07.021
Publication status	Published - Jun 2012
Externally published	Yes

Keywords

Acidosis, Lactic/chemically induced
Aged, 80 and over
Humans
Hypoglycemic Agents/administration & dosage
Kidney/drug effects
Male
Metformin/administration & dosage
Risk Factors

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10.1016/j.diabres.2011.07.021

Cite this

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title = "Metformin-associated lactic acidosis in a patient with normal kidney function",

abstract = "The existence of metformin-induced lactic acidosis has been questioned, in particular in the absence of specific risk factors such as impaired renal function. This report describes the presence of lactic acidosis in a patient with normal kidney function and normal doses of metformin. Subsequent positive rechallenge with metformin confirms causality.",

keywords = "Acidosis, Lactic/chemically induced, Aged, 80 and over, Humans, Hypoglycemic Agents/administration \& dosage, Kidney/drug effects, Male, Metformin/administration \& dosage, Risk Factors",

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AU - van Sloten, T T

AU - Pijpers, E

AU - Stehouwer, C D A

AU - Brouwers, M C G J

PY - 2012/6

Y1 - 2012/6

N2 - The existence of metformin-induced lactic acidosis has been questioned, in particular in the absence of specific risk factors such as impaired renal function. This report describes the presence of lactic acidosis in a patient with normal kidney function and normal doses of metformin. Subsequent positive rechallenge with metformin confirms causality.

AB - The existence of metformin-induced lactic acidosis has been questioned, in particular in the absence of specific risk factors such as impaired renal function. This report describes the presence of lactic acidosis in a patient with normal kidney function and normal doses of metformin. Subsequent positive rechallenge with metformin confirms causality.

KW - Acidosis, Lactic/chemically induced

KW - Aged, 80 and over

KW - Humans

KW - Hypoglycemic Agents/administration & dosage

KW - Kidney/drug effects

KW - Male

KW - Metformin/administration & dosage

KW - Risk Factors

U2 - 10.1016/j.diabres.2011.07.021

DO - 10.1016/j.diabres.2011.07.021

M3 - Article

C2 - 21839535

SN - 0168-8227

VL - 96

SP - e57-58

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 3

ER -

Metformin-associated lactic acidosis in a patient with normal kidney function

Abstract

Keywords

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