Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

Elise M Bekers, Adriana C H van Engen-van Grunsven, Patricia J T A Groenen, Harm Westdorp, Rutger H T Koornstra, Johannes J Bonenkamp, Uta Flucke, Willeke A M Blokx

Research output: Contribution to journalArticleAcademicpeer-review


Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

Original languageEnglish
Pages (from-to)247-51
Number of pages5
JournalVirchows Archives
Issue number2
Publication statusPublished - Feb 2014


  • Adult
  • Aged
  • DNA Mutational Analysis
  • Diagnosis, Differential
  • Female
  • GTP Phosphohydrolases/genetics
  • Humans
  • Melanoma/diagnosis
  • Membrane Proteins/genetics
  • Proto-Oncogene Proteins B-raf/genetics
  • Skin Neoplasms
  • Solitary Fibrous Tumors/diagnosis


Dive into the research topics of 'Metastatic melanoma mimicking solitary fibrous tumor: report of two cases'. Together they form a unique fingerprint.

Cite this