Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

Elise M Bekers; Adriana C H van Engen-van Grunsven; Patricia J T A Groenen; Harm Westdorp; Rutger H T Koornstra; Johannes J Bonenkamp; Uta Flucke; Willeke A M Blokx

doi:10.1007/s00428-014-1542-5

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

Elise M Bekers, Adriana C H van Engen-van Grunsven, Patricia J T A Groenen, Harm Westdorp, Rutger H T Koornstra, Johannes J Bonenkamp, Uta Flucke, Willeke A M Blokx

Department of Pathology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

Original language	English
Pages (from-to)	247-51
Number of pages	5
Journal	Virchows Archives
Volume	464
Issue number	2
DOIs	https://doi.org/10.1007/s00428-014-1542-5
Publication status	Published - Feb 2014

Keywords

Adult
Aged
DNA Mutational Analysis
Diagnosis, Differential
Female
GTP Phosphohydrolases/genetics
Humans
Melanoma/diagnosis
Membrane Proteins/genetics
Proto-Oncogene Proteins B-raf/genetics
Skin Neoplasms
Solitary Fibrous Tumors/diagnosis

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10.1007/s00428-014-1542-5

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title = "Metastatic melanoma mimicking solitary fibrous tumor: report of two cases",

abstract = "Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma. ",

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author = "Bekers, {Elise M} and {van Engen-van Grunsven}, {Adriana C H} and Groenen, {Patricia J T A} and Harm Westdorp and Koornstra, {Rutger H T} and Bonenkamp, {Johannes J} and Uta Flucke and Blokx, {Willeke A M}",

year = "2014",

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doi = "10.1007/s00428-014-1542-5",

language = "English",

volume = "464",

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journal = "Virchows Archives",

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T1 - Metastatic melanoma mimicking solitary fibrous tumor

T2 - report of two cases

AU - Bekers, Elise M

AU - van Engen-van Grunsven, Adriana C H

AU - Groenen, Patricia J T A

AU - Westdorp, Harm

AU - Koornstra, Rutger H T

AU - Bonenkamp, Johannes J

AU - Flucke, Uta

AU - Blokx, Willeke A M

PY - 2014/2

Y1 - 2014/2

N2 - Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

AB - Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

KW - Adult

KW - Aged

KW - DNA Mutational Analysis

KW - Diagnosis, Differential

KW - Female

KW - GTP Phosphohydrolases/genetics

KW - Humans

KW - Melanoma/diagnosis

KW - Membrane Proteins/genetics

KW - Proto-Oncogene Proteins B-raf/genetics

KW - Skin Neoplasms

KW - Solitary Fibrous Tumors/diagnosis

U2 - 10.1007/s00428-014-1542-5

DO - 10.1007/s00428-014-1542-5

M3 - Article

C2 - 24458518

SN - 0945-6317

VL - 464

SP - 247

EP - 251

JO - Virchows Archives

JF - Virchows Archives

IS - 2

ER -

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

Abstract

Keywords

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