TY - JOUR
T1 - Metabolic effects of a 13-weeks lifestyle intervention in older adults
T2 - The Growing Old Together Study
AU - van de Rest, Ondine
AU - Schutte, Bianca A.M.
AU - Deelen, Joris
AU - Stassen, Stephanie A.M.
AU - van den Akker, Erik B.
AU - van Heemst, Diana
AU - Dibbets-Schneider, Petra
AU - van Dipten-van der Veen, Regina A.
AU - Kelderman, Milou
AU - Hankemeier, Thomas
AU - Mooijaart, Simon P.
AU - van der Grond, Jeroen
AU - Houwing-Duistermaat, Jeanine J.
AU - Beekman, Marian
AU - Feskens, Edith J.M.
AU - Slagboom, P. Eline
PY - 2016/1/1
Y1 - 2016/1/1
N2 - For people in their 40s and 50s, lifestyle programs have been shown to improve metabolic health. For older adults, however, it is not clear whether these programs are equally healthy. In the Growing Old Together study, we applied a 13-weeks lifestyle program, with a target of 12.5% caloric restriction and 12.5% increase in energy expenditure through an increase in physical activity, in 164 older adults (mean age=63.2 years; BMI=23-35 kg/m2). Mean weight loss was 4.2% (SE=2.8%) of baseline weight, which is comparable to a previous study in younger adults. Fasting insulin levels, however, showed a much smaller decrease (0.30 mU/L (SE=3.21)) and a more heterogeneous response (range=2.0-29.6 mU/L). Many other parameters of metabolic health, such as blood pressure, and thyroid, glucose and lipid metabolism improved significantly. Many 1H-NMR metabolites changed in a direction previously associated with a low risk of type 2 diabetes and cardiovascular disease and partially independently of weight loss. In conclusion, 25% reduction in energy balance for 13 weeks induced a metabolic health benefit in older adults, monitored by traditional and novel metabolic markers.
AB - For people in their 40s and 50s, lifestyle programs have been shown to improve metabolic health. For older adults, however, it is not clear whether these programs are equally healthy. In the Growing Old Together study, we applied a 13-weeks lifestyle program, with a target of 12.5% caloric restriction and 12.5% increase in energy expenditure through an increase in physical activity, in 164 older adults (mean age=63.2 years; BMI=23-35 kg/m2). Mean weight loss was 4.2% (SE=2.8%) of baseline weight, which is comparable to a previous study in younger adults. Fasting insulin levels, however, showed a much smaller decrease (0.30 mU/L (SE=3.21)) and a more heterogeneous response (range=2.0-29.6 mU/L). Many other parameters of metabolic health, such as blood pressure, and thyroid, glucose and lipid metabolism improved significantly. Many 1H-NMR metabolites changed in a direction previously associated with a low risk of type 2 diabetes and cardiovascular disease and partially independently of weight loss. In conclusion, 25% reduction in energy balance for 13 weeks induced a metabolic health benefit in older adults, monitored by traditional and novel metabolic markers.
KW - Caloric restriction
KW - Healthy ageing
KW - Lifestyle intervention
KW - Metabolic health
KW - Older adults
KW - Physical activity
UR - http://www.scopus.com/inward/record.url?scp=84986550317&partnerID=8YFLogxK
M3 - Article
C2 - 26824634
AN - SCOPUS:84986550317
SN - 1945-4589
VL - 8
SP - 111
EP - 126
JO - Aging
JF - Aging
IS - 1
ER -