Mesenchymal stromal cells for the treatment of critical limb ischemia: context and perspective

H. Gremmels; J.O. Fledderus; M. Teraa; M.C. Verhaar

doi:10.1186/scrt351

Mesenchymal stromal cells for the treatment of critical limb ischemia: context and perspective

H. Gremmels, J.O. Fledderus, M. Teraa, M.C. Verhaar

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic limbs. In this commentary, we discuss a recent study by Gupta and colleagues, one of the first human trials using allogeneic MSCs for CLI, in relation to the current state of knowledge regarding cell therapy for CLI.

Original language	English
Pages (from-to)	140
Number of pages	1
Journal	Stem Cell Research & Therapy [E]
Volume	4
Issue number	6
DOIs	https://doi.org/10.1186/scrt351
Publication status	Published - 2013

Keywords

Bone Marrow Transplantation/methods
Female
Humans
Ischemia/pathology
Leg/pathology
Male
Mesenchymal Stem Cells/cytology
Peripheral Vascular Diseases/therapy

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10.1186/scrt351

http://stemcellres.com/content/4/6/140

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title = "Mesenchymal stromal cells for the treatment of critical limb ischemia: context and perspective",

abstract = "Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic limbs. In this commentary, we discuss a recent study by Gupta and colleagues, one of the first human trials using allogeneic MSCs for CLI, in relation to the current state of knowledge regarding cell therapy for CLI.",

keywords = "Bone Marrow Transplantation/methods, Female, Humans, Ischemia/pathology, Leg/pathology, Male, Mesenchymal Stem Cells/cytology, Peripheral Vascular Diseases/therapy",

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T1 - Mesenchymal stromal cells for the treatment of critical limb ischemia

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AU - Gremmels, H.

AU - Fledderus, J.O.

AU - Teraa, M.

AU - Verhaar, M.C.

PY - 2013

Y1 - 2013

N2 - Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic limbs. In this commentary, we discuss a recent study by Gupta and colleagues, one of the first human trials using allogeneic MSCs for CLI, in relation to the current state of knowledge regarding cell therapy for CLI.

AB - Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic limbs. In this commentary, we discuss a recent study by Gupta and colleagues, one of the first human trials using allogeneic MSCs for CLI, in relation to the current state of knowledge regarding cell therapy for CLI.

KW - Bone Marrow Transplantation/methods

KW - Female

KW - Humans

KW - Ischemia/pathology

KW - Leg/pathology

KW - Male

KW - Mesenchymal Stem Cells/cytology

KW - Peripheral Vascular Diseases/therapy

U2 - 10.1186/scrt351

DO - 10.1186/scrt351

M3 - Article

C2 - 24246031

SN - 1757-6512

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SP - 140

JO - Stem Cell Research & Therapy [E]

JF - Stem Cell Research & Therapy [E]

IS - 6

ER -

Mesenchymal stromal cells for the treatment of critical limb ischemia: context and perspective

Abstract

Keywords

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