Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

Angelica Aguilera-Gomez; Catherine Rabouille

doi:10.1016/j.ydbio.2017.03.029

Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

Angelica Aguilera-Gomez
, Catherine Rabouille^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

Original language	English
Pages (from-to)	310-317
Number of pages	8
Journal	Developmental Biology
Volume	428
Issue number	2
DOIs	https://doi.org/10.1016/j.ydbio.2017.03.029
Publication status	Published - 15 Aug 2017

Keywords

COPII
Cell compartmentalization
Drosophila
ER exit sites
FMR1
Liquid droplets
Liquid-liquid phase separation
Low complexity sequence
Membrane-bound organelles
Membrane-less compartments
Oocyte
Orb
PARP16
S2 cells
Sec16
Secretory pathway
Stress granule
gurken translation
mRNA

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10.1016/j.ydbio.2017.03.029

1-s2.0-S0012160617300131-mainFinal published version, 611 KBLicence: CC BY-NC-ND

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title = "Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila",

abstract = "Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.",

keywords = "COPII, Cell compartmentalization, Drosophila, ER exit sites, FMR1, Liquid droplets, Liquid-liquid phase separation, Low complexity sequence, Membrane-bound organelles, Membrane-less compartments, Oocyte, Orb, PARP16, S2 cells, Sec16, Secretory pathway, Stress granule, gurken translation, mRNA",

author = "Angelica Aguilera-Gomez and Catherine Rabouille",

note = "Funding Information: We thank our colleagues for many discussions on several aspects of this review, especially from the Davis lab (Oxford, UK) on Drosophila P-bodies, and Bram Herpers (Leiden University, the Netherlands) for the micrograph shown in Fig. 1. The work in the Rabouille lab is funded by NWO (De Nederlandse Organisatie voor Wetenschappelijk Onderzoek) and the KNAW (Koninklijke Nederlandse Akademie van Wetenschappen). Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

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doi = "10.1016/j.ydbio.2017.03.029",

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AU - Rabouille, Catherine

N1 - Funding Information: We thank our colleagues for many discussions on several aspects of this review, especially from the Davis lab (Oxford, UK) on Drosophila P-bodies, and Bram Herpers (Leiden University, the Netherlands) for the micrograph shown in Fig. 1. The work in the Rabouille lab is funded by NWO (De Nederlandse Organisatie voor Wetenschappelijk Onderzoek) and the KNAW (Koninklijke Nederlandse Akademie van Wetenschappen). Publisher Copyright: © 2017 The Authors

PY - 2017/8/15

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N2 - Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

AB - Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

KW - COPII

KW - Cell compartmentalization

KW - Drosophila

KW - ER exit sites

KW - FMR1

KW - Liquid droplets

KW - Liquid-liquid phase separation

KW - Low complexity sequence

KW - Membrane-bound organelles

KW - Membrane-less compartments

KW - Oocyte

KW - Orb

KW - PARP16

KW - S2 cells

KW - Sec16

KW - Secretory pathway

KW - Stress granule

KW - gurken translation

KW - mRNA

UR - https://www.scopus.com/pages/publications/85016443781

U2 - 10.1016/j.ydbio.2017.03.029

DO - 10.1016/j.ydbio.2017.03.029

M3 - Review article

C2 - 28377034

AN - SCOPUS:85016443781

SN - 0012-1606

VL - 428

SP - 310

EP - 317

JO - Developmental Biology

JF - Developmental Biology

IS - 2

ER -

Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

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