Mechanisms regulating eosinophil extravasation in asthma

E Knol, Dirk Roos

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Infiltration of eosinophils into tissue allergic inflammation is mediated by a combination of processes. Eosinophil L-selectin and very late activation antigen (VLA-4) can selectively regulate eosinophil adhesion to the endothelium. Activating cytokines, such as interleukin (IL)-5, regulated upon activation in normal T-cells (RANTES) and monocyte chemotactic peptide (MCP)-3 specifically act on eosinophils. Moreover, eosinophils from allergic individuals can be primed for increased adhesion and movement by chemokines released at sites of allergic inflammation. Together, these processes induce a specific infiltration of eosinophils.

Original languageEnglish
Pages (from-to)136s-140s
Number of pages5
JournalEuropean Respiratory Journal, Supplement
Volume22
Publication statusPublished - Aug 1996

Keywords

  • Adhesion
  • Allergy
  • Asthma
  • Chemotaxis
  • Eosinophils
  • Extravasation

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