Mechanical ventilation of mice under general anesthesia during experimental procedures

Ilona van den Brink; Francien van de Pol; Michiel Vaneker; Matthijs Kox; Willem-Jan Schellekens; Merel Ritskes-Hoitinga; Gert Jan Scheffer

doi:10.1038/laban.252

Mechanical ventilation of mice under general anesthesia during experimental procedures

Ilona van den Brink, Francien van de Pol, Michiel Vaneker, Matthijs Kox, Willem-Jan Schellekens, Merel Ritskes-Hoitinga, Gert Jan Scheffer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Mechanical ventilation is frequently used in patients under general anesthesia during invasive procedures. Invasive animal experiments similarly require the maintenance of normal hemodynamic and pulmonary parameters during long-term general anesthesia. The authors describe a method for mechanical ventilation of mice. Mice were ventilated and monitored for up to 8 h of general anesthesia during surgery. Hemodynamic and pulmonary parameters remained within the normal ranges. The authors believe that this ventilation technique can be of great value for experimental procedures in mice that require general anesthesia.

Original language	English
Pages (from-to)	253-7
Number of pages	5
Journal	Lab Animal
Volume	42
Issue number	7
DOIs	https://doi.org/10.1038/laban.252
Publication status	Published - Jul 2013
Externally published	Yes

Keywords

Anesthesia, General/veterinary
Animals
Hemodynamics
Intraoperative Complications/prevention & control
Male
Mice
Mice, Inbred C57BL
Monitoring, Intraoperative/veterinary
Respiration, Artificial/veterinary
Respiratory Function Tests
Surgical Procedures, Operative/veterinary

Access to Document

10.1038/laban.252

Cite this

@article{a0d7e9f8ab214f33a6a041e857263865,

title = "Mechanical ventilation of mice under general anesthesia during experimental procedures",

abstract = "Mechanical ventilation is frequently used in patients under general anesthesia during invasive procedures. Invasive animal experiments similarly require the maintenance of normal hemodynamic and pulmonary parameters during long-term general anesthesia. The authors describe a method for mechanical ventilation of mice. Mice were ventilated and monitored for up to 8 h of general anesthesia during surgery. Hemodynamic and pulmonary parameters remained within the normal ranges. The authors believe that this ventilation technique can be of great value for experimental procedures in mice that require general anesthesia.",

keywords = "Anesthesia, General/veterinary, Animals, Hemodynamics, Intraoperative Complications/prevention & control, Male, Mice, Mice, Inbred C57BL, Monitoring, Intraoperative/veterinary, Respiration, Artificial/veterinary, Respiratory Function Tests, Surgical Procedures, Operative/veterinary",

author = "{van den Brink}, Ilona and {van de Pol}, Francien and Michiel Vaneker and Matthijs Kox and Willem-Jan Schellekens and Merel Ritskes-Hoitinga and Scheffer, {Gert Jan}",

year = "2013",

month = jul,

doi = "10.1038/laban.252",

language = "English",

volume = "42",

pages = "253--7",

journal = "Lab Animal",

issn = "0093-7355",

publisher = "Springer Nature",

number = "7",

}

TY - JOUR

T1 - Mechanical ventilation of mice under general anesthesia during experimental procedures

AU - van den Brink, Ilona

AU - van de Pol, Francien

AU - Vaneker, Michiel

AU - Kox, Matthijs

AU - Schellekens, Willem-Jan

AU - Ritskes-Hoitinga, Merel

AU - Scheffer, Gert Jan

PY - 2013/7

Y1 - 2013/7

N2 - Mechanical ventilation is frequently used in patients under general anesthesia during invasive procedures. Invasive animal experiments similarly require the maintenance of normal hemodynamic and pulmonary parameters during long-term general anesthesia. The authors describe a method for mechanical ventilation of mice. Mice were ventilated and monitored for up to 8 h of general anesthesia during surgery. Hemodynamic and pulmonary parameters remained within the normal ranges. The authors believe that this ventilation technique can be of great value for experimental procedures in mice that require general anesthesia.

AB - Mechanical ventilation is frequently used in patients under general anesthesia during invasive procedures. Invasive animal experiments similarly require the maintenance of normal hemodynamic and pulmonary parameters during long-term general anesthesia. The authors describe a method for mechanical ventilation of mice. Mice were ventilated and monitored for up to 8 h of general anesthesia during surgery. Hemodynamic and pulmonary parameters remained within the normal ranges. The authors believe that this ventilation technique can be of great value for experimental procedures in mice that require general anesthesia.

KW - Anesthesia, General/veterinary

KW - Animals

KW - Hemodynamics

KW - Intraoperative Complications/prevention & control

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Monitoring, Intraoperative/veterinary

KW - Respiration, Artificial/veterinary

KW - Respiratory Function Tests

KW - Surgical Procedures, Operative/veterinary

U2 - 10.1038/laban.252

DO - 10.1038/laban.252

M3 - Article

C2 - 23783316

SN - 0093-7355

VL - 42

SP - 253

EP - 257

JO - Lab Animal

JF - Lab Animal

IS - 7

ER -

Mechanical ventilation of mice under general anesthesia during experimental procedures

Abstract

Keywords

Access to Document

Fingerprint

Cite this