TY - JOUR
T1 - Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition
AU - Rohrmann, Sabine
AU - Linseisen, Jakob
AU - Overvad, Kim
AU - Wurtz, Anne Mette Lund
AU - Roswall, Nina
AU - Tjonneland, Anne
AU - Boutron-Ruault, Marie-Christine
AU - Racine, Antoine
AU - Bastide, Nadia
AU - Palli, Domenico
AU - Agnoli, Claudia
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Weikert, Steffen
AU - Steffen, Annika
AU - Kuehn, Tilman
AU - Li, Kuanrong
AU - Khaw, Kay-Tee
AU - Wareham, Nicholas J.
AU - Bradbury, Kathryn E.
AU - Peppa, Eleni
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Bueno-de-Mesquita, H. Bas
AU - Peeters, Petra H. M.
AU - Hjartaker, Anette
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - Jakszyn, Paula
AU - Dorronsoro, Miren
AU - Barricarte, Aurelio
AU - Santiuste de Pablos, Carmen
AU - Molina-Montes, Esther
AU - Alonso de la Torre, Ramon
AU - Ericson, Ulrika
AU - Sonestedt, Emily
AU - Johansson, Mattias
AU - Ljungberg, Borje
AU - Freisling, Heinz
AU - Romieu, Isabelle
AU - Cross, Amanda J.
AU - Vergnaud, Anne-Claire
AU - Riboli, Elio
AU - Boeing, Heiner
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR=1.36, 95% CI 1.14-1.62; calibrated, per 50 g/day) and processed meat (HR=1.78, 95% CI 1.05-3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction=0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear.What's new? Kidney cancer strikes different populations with different frequency, with developed nations seeing more cases. In this paper, the authors investigate whether certain elements of diet might correlate with increased incidence of renal cell carcinoma. Using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assessed the amount of meat and fish consumed in populations representing a wide range of dietary habits. They then correlated this data with renal cell carcinoma incidence. They found no effect from eating fish; consuming red and processed meats did increase risk in women, but not in men.
AB - Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country-specific dietary assessment instruments; 24-hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR=1.36, 95% CI 1.14-1.62; calibrated, per 50 g/day) and processed meat (HR=1.78, 95% CI 1.05-3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women (p interaction=0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear.What's new? Kidney cancer strikes different populations with different frequency, with developed nations seeing more cases. In this paper, the authors investigate whether certain elements of diet might correlate with increased incidence of renal cell carcinoma. Using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assessed the amount of meat and fish consumed in populations representing a wide range of dietary habits. They then correlated this data with renal cell carcinoma incidence. They found no effect from eating fish; consuming red and processed meats did increase risk in women, but not in men.
KW - renal cell cancer
KW - cohort study
KW - red meat
KW - processed meat
KW - FOOD-FREQUENCY QUESTIONNAIRE
KW - 24-HOUR DIETARY RECALLS
KW - LIPID-PEROXIDATION
KW - POOLED ANALYSIS
KW - KIDNEY CANCER
KW - CALIBRATION
KW - EPIDEMIOLOGY
KW - VEGETABLES
KW - RATIONALE
KW - COOKING
U2 - 10.1002/ijc.29236
DO - 10.1002/ijc.29236
M3 - Article
SN - 0020-7136
VL - 136
SP - E423-E431
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 5
ER -