Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review

M. C. Punt; M. L. Waning; E. P. Mauser-Bunschoten; M. J.H.A. Kruip; J. Eikenboom; L. Nieuwenhuizen; A. B.U. Makelburg; M. H.E. Driessens; J. J. Duvekot; M. Peters; J. M. Middeldorp; K. W.M. Bloemenkamp; R. E.G. Schutgens; A. T. Lely; K. P.M. Van Galen

doi:10.1016/j.blre.2019.100633

Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review

M. C. Punt^*, M. L. Waning, E. P. Mauser-Bunschoten, M. J.H.A. Kruip, J. Eikenboom, L. Nieuwenhuizen, A. B.U. Makelburg, M. H.E. Driessens, J. J. Duvekot, M. Peters, J. M. Middeldorp, K. W.M. Bloemenkamp, R. E.G. Schutgens, A. T. Lely, K. P.M. Van Galen

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Women with Von Willebrand disease (VWD) have an increased risk of developing postpartum hemorrhage (PPH). Our aim is to evaluate peripartum management strategies in relation to maternal and neonatal bleeding complications in VWD. Electronic databases were searched up to January 2019. Seventy-one case-reports and -series and 16 cohort studies were selected, including 811 deliveries. Cohort studies reported primary PPH in 32% and secondary PPH in 13% of the women. The overall primary PPH incidence in the individual patient data was 34%, similar between women who received prophylactic treatment to prevent PPH and those who didn't. Neonatal bleeding events were reported in 4.6% of deliveries. Overall, the available evidence on peripartum management in women with VWD was of low quality. The ongoing high risk for PPH is evident, despite prophylactic treatment, as well as the need for higher quality evidence from larger prospective cohort studies to improve management strategies.

Original language	English
Article number	100633
Number of pages	9
Journal	Blood Reviews
Volume	39
DOIs	https://doi.org/10.1016/j.blre.2019.100633
Publication status	Published - Jan 2020

Keywords

Peripartum period
Postpartum hemorrhage
Pregnancy
Prophylactic treatment
von Willebrand disease

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Punt, M. C., Waning, M. L., Mauser-Bunschoten, E. P., Kruip, M. J. H. A., Eikenboom, J., Nieuwenhuizen, L., Makelburg, A. B. U., Driessens, M. H. E., Duvekot, J. J., Peters, M., Middeldorp, J. M., Bloemenkamp, K. W. M., Schutgens, R. E. G., Lely, A. T., & Van Galen, K. P. M. (2020). Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review. Blood Reviews, 39, Article 100633. https://doi.org/10.1016/j.blre.2019.100633

@article{b635991a16404e9ab83ce8477522b7bd,

title = "Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review",

abstract = "Women with Von Willebrand disease (VWD) have an increased risk of developing postpartum hemorrhage (PPH). Our aim is to evaluate peripartum management strategies in relation to maternal and neonatal bleeding complications in VWD. Electronic databases were searched up to January 2019. Seventy-one case-reports and -series and 16 cohort studies were selected, including 811 deliveries. Cohort studies reported primary PPH in 32% and secondary PPH in 13% of the women. The overall primary PPH incidence in the individual patient data was 34%, similar between women who received prophylactic treatment to prevent PPH and those who didn't. Neonatal bleeding events were reported in 4.6% of deliveries. Overall, the available evidence on peripartum management in women with VWD was of low quality. The ongoing high risk for PPH is evident, despite prophylactic treatment, as well as the need for higher quality evidence from larger prospective cohort studies to improve management strategies.",

keywords = "Peripartum period, Postpartum hemorrhage, Pregnancy, Prophylactic treatment, von Willebrand disease",

author = "Punt, {M. C.} and Waning, {M. L.} and Mauser-Bunschoten, {E. P.} and Kruip, {M. J.H.A.} and J. Eikenboom and L. Nieuwenhuizen and Makelburg, {A. B.U.} and Driessens, {M. H.E.} and Duvekot, {J. J.} and M. Peters and Middeldorp, {J. M.} and Bloemenkamp, {K. W.M.} and Schutgens, {R. E.G.} and Lely, {A. T.} and {Van Galen}, {K. P.M.}",

year = "2020",

month = jan,

doi = "10.1016/j.blre.2019.100633",

language = "English",

volume = "39",

journal = "Blood Reviews",

issn = "0268-960X",

publisher = "Churchill Livingstone",

}

Punt, MC, Waning, ML, Mauser-Bunschoten, EP, Kruip, MJHA, Eikenboom, J, Nieuwenhuizen, L, Makelburg, ABU, Driessens, MHE, Duvekot, JJ, Peters, M, Middeldorp, JM, Bloemenkamp, KWM , Schutgens, REG , Lely, AT & Van Galen, KPM 2020, 'Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review', Blood Reviews, vol. 39, 100633. https://doi.org/10.1016/j.blre.2019.100633

TY - JOUR

T1 - Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease

T2 - A systematic review

AU - Punt, M. C.

AU - Waning, M. L.

AU - Mauser-Bunschoten, E. P.

AU - Kruip, M. J.H.A.

AU - Eikenboom, J.

AU - Nieuwenhuizen, L.

AU - Makelburg, A. B.U.

AU - Driessens, M. H.E.

AU - Duvekot, J. J.

AU - Peters, M.

AU - Middeldorp, J. M.

AU - Bloemenkamp, K. W.M.

AU - Schutgens, R. E.G.

AU - Lely, A. T.

AU - Van Galen, K. P.M.

PY - 2020/1

Y1 - 2020/1

N2 - Women with Von Willebrand disease (VWD) have an increased risk of developing postpartum hemorrhage (PPH). Our aim is to evaluate peripartum management strategies in relation to maternal and neonatal bleeding complications in VWD. Electronic databases were searched up to January 2019. Seventy-one case-reports and -series and 16 cohort studies were selected, including 811 deliveries. Cohort studies reported primary PPH in 32% and secondary PPH in 13% of the women. The overall primary PPH incidence in the individual patient data was 34%, similar between women who received prophylactic treatment to prevent PPH and those who didn't. Neonatal bleeding events were reported in 4.6% of deliveries. Overall, the available evidence on peripartum management in women with VWD was of low quality. The ongoing high risk for PPH is evident, despite prophylactic treatment, as well as the need for higher quality evidence from larger prospective cohort studies to improve management strategies.

AB - Women with Von Willebrand disease (VWD) have an increased risk of developing postpartum hemorrhage (PPH). Our aim is to evaluate peripartum management strategies in relation to maternal and neonatal bleeding complications in VWD. Electronic databases were searched up to January 2019. Seventy-one case-reports and -series and 16 cohort studies were selected, including 811 deliveries. Cohort studies reported primary PPH in 32% and secondary PPH in 13% of the women. The overall primary PPH incidence in the individual patient data was 34%, similar between women who received prophylactic treatment to prevent PPH and those who didn't. Neonatal bleeding events were reported in 4.6% of deliveries. Overall, the available evidence on peripartum management in women with VWD was of low quality. The ongoing high risk for PPH is evident, despite prophylactic treatment, as well as the need for higher quality evidence from larger prospective cohort studies to improve management strategies.

KW - Peripartum period

KW - Postpartum hemorrhage

KW - Pregnancy

KW - Prophylactic treatment

KW - von Willebrand disease

UR - http://www.scopus.com/inward/record.url?scp=85075458685&partnerID=8YFLogxK

U2 - 10.1016/j.blre.2019.100633

DO - 10.1016/j.blre.2019.100633

M3 - Review article

C2 - 31718817

SN - 0268-960X

VL - 39

JO - Blood Reviews

JF - Blood Reviews

M1 - 100633

ER -

Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review

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Keywords

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