Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes

K. Geneugelijk; E. Spierings

doi:10.1111/iji.12359

Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes

K. Geneugelijk^*, E. Spierings

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor–recipient compatibility. The PIRCHE algorithm determines donor–recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation. This review describes the theory of the algorithm, its application in transplantation, and highlights the future perspectives on the clinical application of the PIRCHE algorithm.

Original language	English
Pages (from-to)	41-53
Number of pages	13
Journal	International Journal of Immunogenetics
Volume	45
Issue number	2
Early online date	21 Feb 2018
DOIs	https://doi.org/10.1111/iji.12359
Publication status	Published - Apr 2018

Keywords

epitopes
histocompatibility
human leucocyte antigen
matching
PIRCHE
transplantation

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10.1111/iji.12359

Int J Immunogenetics - 2018 - Geneugelijk - Matching donor and recipient based on predicted indirectly recognizable humanFinal published version, 1.59 MBLicence: Taverne

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title = "Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes",

abstract = "The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor–recipient compatibility. The PIRCHE algorithm determines donor–recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation. This review describes the theory of the algorithm, its application in transplantation, and highlights the future perspectives on the clinical application of the PIRCHE algorithm.",

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AU - Geneugelijk, K.

AU - Spierings, E.

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N2 - The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor–recipient compatibility. The PIRCHE algorithm determines donor–recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation. This review describes the theory of the algorithm, its application in transplantation, and highlights the future perspectives on the clinical application of the PIRCHE algorithm.

AB - The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor–recipient compatibility. The PIRCHE algorithm determines donor–recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation. This review describes the theory of the algorithm, its application in transplantation, and highlights the future perspectives on the clinical application of the PIRCHE algorithm.

KW - epitopes

KW - histocompatibility

KW - human leucocyte antigen

KW - matching

KW - PIRCHE

KW - transplantation

UR - https://www.scopus.com/pages/publications/85042202354

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DO - 10.1111/iji.12359

M3 - Review article

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EP - 53

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 2

ER -

Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes

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Keywords

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