Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome

Bas W M Van Balkom; Renske A. Van Gestel; Jos F H M Brouwers; Jeroen Krijgsveld; Aloysius G M Tielens; Albert J R Heck; Jaap J. Van Hellemond

doi:10.1021/pr050036w

Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome

Bas W M Van Balkom^*
, Renske A. Van Gestel
, Jos F H M Brouwers
, Jeroen Krijgsveld
, Aloysius G M Tielens
, Albert J R Heck
, Jaap J. Van Hellemond

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

104 Citations (Scopus)

Abstract

Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S. mansoni tegumental outer-surface structure proteome by 1D SDS-PAGE and LC-MS/MS and an EST-database from the ongoing genome-sequencing project. We identified 740 proteins of which 43 were tegument-specific. Many of these proteins show no homology to any nonschistosomal protein, demonstrating that the schistosomal outer-surface comprises specific and unique proteins, likely to be critical for parasite survival.

Original language	English
Pages (from-to)	958-966
Number of pages	9
Journal	Journal of Proteome Research
Volume	4
Issue number	3
DOIs	https://doi.org/10.1021/pr050036w
Publication status	Published - 1 May 2005

Keywords

Host-parasite interaction
Immune evasion
Schistosomiasis

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10.1021/pr050036w

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title = "Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome",

abstract = "Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S. mansoni tegumental outer-surface structure proteome by 1D SDS-PAGE and LC-MS/MS and an EST-database from the ongoing genome-sequencing project. We identified 740 proteins of which 43 were tegument-specific. Many of these proteins show no homology to any nonschistosomal protein, demonstrating that the schistosomal outer-surface comprises specific and unique proteins, likely to be critical for parasite survival.",

keywords = "Host-parasite interaction, Immune evasion, Schistosomiasis",

author = "\{Van Balkom\}, \{Bas W M\} and \{Van Gestel\}, \{Renske A.\} and Brouwers, \{Jos F H M\} and Jeroen Krijgsveld and Tielens, \{Aloysius G M\} and Heck, \{Albert J R\} and \{Van Hellemond\}, \{Jaap J.\}",

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AU - Van Balkom, Bas W M

AU - Van Gestel, Renske A.

AU - Brouwers, Jos F H M

AU - Krijgsveld, Jeroen

AU - Tielens, Aloysius G M

AU - Heck, Albert J R

AU - Van Hellemond, Jaap J.

PY - 2005/5/1

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AB - Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S. mansoni tegumental outer-surface structure proteome by 1D SDS-PAGE and LC-MS/MS and an EST-database from the ongoing genome-sequencing project. We identified 740 proteins of which 43 were tegument-specific. Many of these proteins show no homology to any nonschistosomal protein, demonstrating that the schistosomal outer-surface comprises specific and unique proteins, likely to be critical for parasite survival.

KW - Host-parasite interaction

KW - Immune evasion

KW - Schistosomiasis

UR - https://www.scopus.com/pages/publications/20844458058

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JO - Journal of Proteome Research

JF - Journal of Proteome Research

IS - 3

ER -

Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome

Abstract

Keywords

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