Markers of amyloid-β deposition and burden of enlarged perivascular spaces in patients with cognitive impairment and small vessel disease

Ana Sofia Costa; Lieza G Exalto; Wiesje M van der Flier; Charlotte E Teunissen; Frederik Barkhof; Hugo J Kuijf; Geert Jan Biessels

doi:10.1177/13872877241296012

Markers of amyloid-β deposition and burden of enlarged perivascular spaces in patients with cognitive impairment and small vessel disease

Ana Sofia Costa, Lieza G Exalto, Wiesje M van der Flier, Charlotte E Teunissen, Frederik Barkhof, Hugo J Kuijf, Geert Jan Biessels,

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

MRI-visible enlarged perivascular spaces (EPVS) are common in patients with cognitive impairment and possibly linked to Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In a study of memory clinic patients (n = 450; mean age 66.5 ± 7.45, 45.8% female), we investigated CSF amyloid-β (Aβ) 1-42 (AD biomarker) and strictly lobar microbleeds (CAA marker) in relation to centrum semiovale EPVS (CSO-EPVS). Age-controlled analyses showed that severe CSO-EPVS associated with Aβ status (odds ratio [OR] = 1.51, 95%CI = 1.02-2.24), but not strictly lobar microbleeds (OR = 1.39, 95%CI = 0.92-2.11), with no significant Aβ status and microbleeds interaction. This implies that in this setting, severe CSO-EPVS is not a specific indicator of CAA.

Original language	English
Pages (from-to)	981-986
Number of pages	6
Journal	Journal of Alzheimer's disease : JAD
Volume	102
Issue number	4
Early online date	11 Nov 2024
DOIs	https://doi.org/10.1177/13872877241296012
Publication status	Published - Dec 2024

Keywords

Alzheimer's disease
amyloid-β accumulation
cerebral amyloid angiopathy
memory clinic
perivascular spaces
small vessel disease
strictly lobar microbleeds

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10.1177/13872877241296012

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title = "Markers of amyloid-β deposition and burden of enlarged perivascular spaces in patients with cognitive impairment and small vessel disease",

abstract = "MRI-visible enlarged perivascular spaces (EPVS) are common in patients with cognitive impairment and possibly linked to Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In a study of memory clinic patients (n = 450; mean age 66.5 ± 7.45, 45.8% female), we investigated CSF amyloid-β (Aβ) 1-42 (AD biomarker) and strictly lobar microbleeds (CAA marker) in relation to centrum semiovale EPVS (CSO-EPVS). Age-controlled analyses showed that severe CSO-EPVS associated with Aβ status (odds ratio [OR] = 1.51, 95%CI = 1.02-2.24), but not strictly lobar microbleeds (OR = 1.39, 95%CI = 0.92-2.11), with no significant Aβ status and microbleeds interaction. This implies that in this setting, severe CSO-EPVS is not a specific indicator of CAA. ",

keywords = "Alzheimer's disease, amyloid-β accumulation, cerebral amyloid angiopathy, memory clinic, perivascular spaces, small vessel disease, strictly lobar microbleeds",

author = "Costa, {Ana Sofia} and Exalto, {Lieza G} and {van der Flier}, {Wiesje M} and Teunissen, {Charlotte E} and Frederik Barkhof and Kuijf, {Hugo J} and Biessels, {Geert Jan}",

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language = "English",

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AU - Costa, Ana Sofia

AU - Exalto, Lieza G

AU - van der Flier, Wiesje M

AU - Teunissen, Charlotte E

AU - Barkhof, Frederik

AU - Kuijf, Hugo J

AU - Biessels, Geert Jan

PY - 2024/12

Y1 - 2024/12

N2 - MRI-visible enlarged perivascular spaces (EPVS) are common in patients with cognitive impairment and possibly linked to Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In a study of memory clinic patients (n = 450; mean age 66.5 ± 7.45, 45.8% female), we investigated CSF amyloid-β (Aβ) 1-42 (AD biomarker) and strictly lobar microbleeds (CAA marker) in relation to centrum semiovale EPVS (CSO-EPVS). Age-controlled analyses showed that severe CSO-EPVS associated with Aβ status (odds ratio [OR] = 1.51, 95%CI = 1.02-2.24), but not strictly lobar microbleeds (OR = 1.39, 95%CI = 0.92-2.11), with no significant Aβ status and microbleeds interaction. This implies that in this setting, severe CSO-EPVS is not a specific indicator of CAA.

AB - MRI-visible enlarged perivascular spaces (EPVS) are common in patients with cognitive impairment and possibly linked to Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In a study of memory clinic patients (n = 450; mean age 66.5 ± 7.45, 45.8% female), we investigated CSF amyloid-β (Aβ) 1-42 (AD biomarker) and strictly lobar microbleeds (CAA marker) in relation to centrum semiovale EPVS (CSO-EPVS). Age-controlled analyses showed that severe CSO-EPVS associated with Aβ status (odds ratio [OR] = 1.51, 95%CI = 1.02-2.24), but not strictly lobar microbleeds (OR = 1.39, 95%CI = 0.92-2.11), with no significant Aβ status and microbleeds interaction. This implies that in this setting, severe CSO-EPVS is not a specific indicator of CAA.

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KW - amyloid-β accumulation

KW - cerebral amyloid angiopathy

KW - memory clinic

KW - perivascular spaces

KW - small vessel disease

KW - strictly lobar microbleeds

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ER -

Markers of amyloid-β deposition and burden of enlarged perivascular spaces in patients with cognitive impairment and small vessel disease

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