@article{f6ae18cb5b964222af665ee9daa03c31,
title = "Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance",
abstract = "Bertolini et al. report that long-range chromatin interactions in neural stem cells (NSCs) are enriched in Sox2-bound enhancers; in Sox2-deleted NSCs, interactions are reduced. Genes downregulated in Sox2-deleted cells are enriched in interactions with enhancers normally Sox2-bound. Overexpression of Socs3, a gene downregulated in mutant NSCs, rescues long-term NSC self-renewal.",
keywords = "ChIA-PET, chromatin connectivity, neural stem cells, SOX2, transcription factors",
author = "Bertolini, \{Jessica A.\} and Rebecca Favaro and Yanfen Zhu and Miriam Pagin and Ngan, \{Chew Yee\} and Wong, \{Chee Hong\} and Harianto Tjong and Vermunt, \{Marit W.\} and Ben Martynoga and Cristiana Barone and Jessica Mariani and Cardozo, \{Marcos Juli{\'a}n\} and Noemi Tabanera and Federico Zambelli and Sara Mercurio and Sergio Ottolenghi and Paul Robson and Creyghton, \{Menno P.\} and Paola Bovolenta and Giulio Pavesi and Francois Guillemot and Nicolis, \{Silvia K.\} and Wei, \{Chia Lin\}",
note = "Funding Information: We thank Daofeng Li and Ting Wang (Washington University, http://wang.wustl.edu/ ) for helping us host and visualize our genomic data on the WashU browser. We thank Dr. Tae-Kyung Kim for the c-fos enhancers. Research reported in this publication was supported by Telethon , AIRC , Regione Lombardia ASTIL , Fondazione Cariplo , ERANET ImprovVision ( NEURON8-Full-815-091 to S.K.N.), MINECO ( BFU2013-43213-P and BFU2016-75412-R with FEDER support), CIBERER , ISCIII , ERANET/PCIN - 2015-176-C02-01 , an Institutional Grant from Fundaci{\'o}n Ramon Areces and Banco Santander (to P.B.), the 4DN ( U54 DK107967 ), ENCODE Consortia ( UM1 HG009409 to C.-L.W.), NCI ( P30CA034196 to C.-L.W. and C.Y.N. ), the Francis Crick Institute (which receives its core funding from Cancer Research UK; FC0010089 ), the UK Medical Research Council ( FC0010089 ), the Wellcome Trust ( FC0010089 to F.G. and B.M.), and the UK Biotechnology and Biological Sciences Research Council ( BB/K005316/1 to F.G.). J.B. was supported by short-term fellowships from EMBO and Fondazione Cariplo for two stays in Madrid. Funding Information: We thank Daofeng Li and Ting Wang (Washington University, http://wang.wustl.edu/) for helping us host and visualize our genomic data on the WashU browser. We thank Dr. Tae-Kyung Kim for the c-fos enhancers. Research reported in this publication was supported by Telethon, AIRC, Regione Lombardia ASTIL, Fondazione Cariplo, ERANET ImprovVision (NEURON8-Full-815-091 to S.K.N.), MINECO (BFU2013-43213-P and BFU2016-75412-R with FEDER support), CIBERER, ISCIII, ERANET/PCIN-2015-176-C02-01, an Institutional Grant from Fundaci{\'o}n Ramon Areces and Banco Santander (to P.B.), the 4DN (U54 DK107967), ENCODE Consortia (UM1 HG009409 to C.-L.W.), NCI (P30CA034196 to C.-L.W. and C.Y.N.), the Francis Crick Institute (which receives its core funding from Cancer Research UK; FC0010089), the UK Medical Research Council (FC0010089), the Wellcome Trust (FC0010089 to F.G. and B.M.), and the UK Biotechnology and Biological Sciences Research Council (BB/K005316/1 to F.G.). J.B. was supported by short-term fellowships from EMBO and Fondazione Cariplo for two stays in Madrid. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = mar,
day = "7",
doi = "10.1016/j.stem.2019.02.004",
language = "English",
volume = "24",
pages = "462--476.e6",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "3",
}