Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Andrada Turcas; Sarah M. Kelly; Valérie Bernier-Chastagner; Stephanie Bolle; Alison Cameron; Coreen Corning; Enrico Clementel; Karin Dieckmann; Raquel Davila Fajardo; Mark N. Gaze; Anne Laprie; Henriette Magelssen; Silvia Meroni; Emanuele Pignoli; Akmal Safwat; Giovanni Scarzello; James Talbot; Beate Timmermann; Tom Boterberg; Henry C. Mandeville

doi:10.1016/j.radonc.2023.109810

Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Andrada Turcas^*
, Sarah M. Kelly
, Valérie Bernier-Chastagner
, Stephanie Bolle
, Alison Cameron
, Coreen Corning
, Enrico Clementel
, Karin Dieckmann
, Raquel Davila Fajardo
, Mark N. Gaze
, Anne Laprie
, Henriette Magelssen
, Silvia Meroni
, Emanuele Pignoli
, Akmal Safwat
, Giovanni Scarzello
, James Talbot
, Beate Timmermann
, Tom Boterberg
, Henry C. Mandeville

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Downloads (Pure)

Abstract

Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

Original language	English
Article number	109810
Pages (from-to)	1-5
Number of pages	5
Journal	Radiotherapy and Oncology
Volume	187
DOIs	https://doi.org/10.1016/j.radonc.2023.109810
Publication status	Published - Oct 2023

Keywords

Clinical trial
Pediatrics
Quality assurance
Radiotherapy
Vertebrae

Access to Document

10.1016/j.radonc.2023.109810Licence: CC BY-NC-ND

1-s2.0-S0167814023003675-mainFinal published version, 1.54 MBLicence: CC BY-NC-ND

Cite this

Turcas, A., Kelly, S. M., Bernier-Chastagner, V., Bolle, S., Cameron, A., Corning, C., Clementel, E., Dieckmann, K., Davila Fajardo, R., Gaze, M. N., Laprie, A., Magelssen, H., Meroni, S., Pignoli, E., Safwat, A., Scarzello, G., Talbot, J., Timmermann, B., Boterberg, T., & Mandeville, H. C. (2023). Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience. Radiotherapy and Oncology, 187, 1-5. Article 109810. https://doi.org/10.1016/j.radonc.2023.109810

@article{6fe9c79ced7940f6b3f491fe48a8a6ab,

title = "Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience",

abstract = "Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.",

keywords = "Clinical trial, Pediatrics, Quality assurance, Radiotherapy, Vertebrae",

author = "Andrada Turcas and Kelly, \{Sarah M.\} and Val{\'e}rie Bernier-Chastagner and Stephanie Bolle and Alison Cameron and Coreen Corning and Enrico Clementel and Karin Dieckmann and \{Davila Fajardo\}, Raquel and Gaze, \{Mark N.\} and Anne Laprie and Henriette Magelssen and Silvia Meroni and Emanuele Pignoli and Akmal Safwat and Giovanni Scarzello and James Talbot and Beate Timmermann and Tom Boterberg and Mandeville, \{Henry C.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = oct,

doi = "10.1016/j.radonc.2023.109810",

language = "English",

volume = "187",

pages = "1--5",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

}

Turcas, A, Kelly, SM, Bernier-Chastagner, V, Bolle, S, Cameron, A, Corning, C, Clementel, E, Dieckmann, K, Davila Fajardo, R, Gaze, MN, Laprie, A, Magelssen, H, Meroni, S, Pignoli, E, Safwat, A, Scarzello, G, Talbot, J, Timmermann, B, Boterberg, T & Mandeville, HC 2023, 'Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience', Radiotherapy and Oncology, vol. 187, 109810, pp. 1-5. https://doi.org/10.1016/j.radonc.2023.109810

TY - JOUR

T1 - Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials

T2 - Initial QUARTET experience

AU - Turcas, Andrada

AU - Kelly, Sarah M.

AU - Bernier-Chastagner, Valérie

AU - Bolle, Stephanie

AU - Cameron, Alison

AU - Corning, Coreen

AU - Clementel, Enrico

AU - Dieckmann, Karin

AU - Davila Fajardo, Raquel

AU - Gaze, Mark N.

AU - Laprie, Anne

AU - Magelssen, Henriette

AU - Meroni, Silvia

AU - Pignoli, Emanuele

AU - Safwat, Akmal

AU - Scarzello, Giovanni

AU - Talbot, James

AU - Timmermann, Beate

AU - Boterberg, Tom

AU - Mandeville, Henry C.

PY - 2023/10

Y1 - 2023/10

N2 - Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

AB - Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

KW - Clinical trial

KW - Pediatrics

KW - Quality assurance

KW - Radiotherapy

KW - Vertebrae

UR - https://www.scopus.com/pages/publications/85165670475

U2 - 10.1016/j.radonc.2023.109810

DO - 10.1016/j.radonc.2023.109810

M3 - Article

C2 - 37468069

AN - SCOPUS:85165670475

SN - 0167-8140

VL - 187

SP - 1

EP - 5

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

M1 - 109810

ER -

Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this