Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Andrada Turcas; Sarah M. Kelly; Valérie Bernier-Chastagner; Stephanie Bolle; Alison Cameron; Coreen Corning; Enrico Clementel; Karin Dieckmann; Raquel Davila Fajardo; Mark N. Gaze; Anne Laprie; Henriette Magelssen; Silvia Meroni; Emanuele Pignoli; Akmal Safwat; Giovanni Scarzello; James Talbot; Beate Timmermann; Tom Boterberg; Henry C. Mandeville

doi:10.1016/j.radonc.2023.109810

Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Andrada Turcas^*, Sarah M. Kelly, Valérie Bernier-Chastagner, Stephanie Bolle, Alison Cameron, Coreen Corning, Enrico Clementel, Karin Dieckmann, Raquel Davila Fajardo, Mark N. Gaze, Anne Laprie, Henriette Magelssen, Silvia Meroni, Emanuele Pignoli, Akmal Safwat, Giovanni Scarzello, James Talbot, Beate Timmermann, Tom Boterberg, Henry C. Mandeville

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

Original language	English
Article number	109810
Pages (from-to)	1-5
Number of pages	5
Journal	Radiotherapy and Oncology
Volume	187
DOIs	https://doi.org/10.1016/j.radonc.2023.109810
Publication status	Published - Oct 2023

Keywords

Clinical trial
Pediatrics
Quality assurance
Radiotherapy
Vertebrae

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10.1016/j.radonc.2023.109810Licence: CC BY-NC-ND

1-s2.0-S0167814023003675-mainFinal published version, 1.54 MBLicence: CC BY-NC-ND

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Turcas, A., Kelly, S. M., Bernier-Chastagner, V., Bolle, S., Cameron, A., Corning, C., Clementel, E., Dieckmann, K., Davila Fajardo, R., Gaze, M. N., Laprie, A., Magelssen, H., Meroni, S., Pignoli, E., Safwat, A., Scarzello, G., Talbot, J., Timmermann, B., Boterberg, T., & Mandeville, H. C. (2023). Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience. Radiotherapy and Oncology, 187, 1-5. Article 109810. https://doi.org/10.1016/j.radonc.2023.109810

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title = "Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience",

abstract = "Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.",

keywords = "Clinical trial, Pediatrics, Quality assurance, Radiotherapy, Vertebrae",

author = "Andrada Turcas and Kelly, {Sarah M.} and Val{\'e}rie Bernier-Chastagner and Stephanie Bolle and Alison Cameron and Coreen Corning and Enrico Clementel and Karin Dieckmann and {Davila Fajardo}, Raquel and Gaze, {Mark N.} and Anne Laprie and Henriette Magelssen and Silvia Meroni and Emanuele Pignoli and Akmal Safwat and Giovanni Scarzello and James Talbot and Beate Timmermann and Tom Boterberg and Mandeville, {Henry C.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = oct,

doi = "10.1016/j.radonc.2023.109810",

language = "English",

volume = "187",

pages = "1--5",

journal = "Radiotherapy and Oncology",

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Turcas, A, Kelly, SM, Bernier-Chastagner, V, Bolle, S, Cameron, A, Corning, C, Clementel, E, Dieckmann, K, Davila Fajardo, R, Gaze, MN, Laprie, A, Magelssen, H, Meroni, S, Pignoli, E, Safwat, A, Scarzello, G, Talbot, J, Timmermann, B, Boterberg, T & Mandeville, HC 2023, 'Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience', Radiotherapy and Oncology, vol. 187, 109810, pp. 1-5. https://doi.org/10.1016/j.radonc.2023.109810

TY - JOUR

T1 - Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials

T2 - Initial QUARTET experience

AU - Turcas, Andrada

AU - Kelly, Sarah M.

AU - Bernier-Chastagner, Valérie

AU - Bolle, Stephanie

AU - Cameron, Alison

AU - Corning, Coreen

AU - Clementel, Enrico

AU - Dieckmann, Karin

AU - Davila Fajardo, Raquel

AU - Gaze, Mark N.

AU - Laprie, Anne

AU - Magelssen, Henriette

AU - Meroni, Silvia

AU - Pignoli, Emanuele

AU - Safwat, Akmal

AU - Scarzello, Giovanni

AU - Talbot, James

AU - Timmermann, Beate

AU - Boterberg, Tom

AU - Mandeville, Henry C.

PY - 2023/10

Y1 - 2023/10

N2 - Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

AB - Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

KW - Clinical trial

KW - Pediatrics

KW - Quality assurance

KW - Radiotherapy

KW - Vertebrae

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U2 - 10.1016/j.radonc.2023.109810

DO - 10.1016/j.radonc.2023.109810

M3 - Article

C2 - 37468069

AN - SCOPUS:85165670475

SN - 0167-8140

VL - 187

SP - 1

EP - 5

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

M1 - 109810

ER -

Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

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