Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Johannes A Rijken; Berry de Vos; C René Leemans; G J C Ben Zwezerijnen; Pim de Graaf; Erik F Hensen; Koen M A Dreijerink; Chris Dickhoff; Petr Symersky

doi:10.1016/j.athoracsur.2019.05.037

Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Johannes A Rijken, Berry de Vos, C René Leemans, G J C Ben Zwezerijnen, Pim de Graaf, Erik F Hensen, Koen M A Dreijerink, Chris Dickhoff, Petr Symersky

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.

Original language	English
Pages (from-to)	e87-e90
Journal	The Annals of Thoracic Surgery
Volume	109
Issue number	2
DOIs	https://doi.org/10.1016/j.athoracsur.2019.05.037
Publication status	Published - Feb 2020
Externally published	Yes

Keywords

Adult
DNA Mutational Analysis
DNA, Neoplasm/genetics
Head and Neck Neoplasms/diagnosis
Humans
Magnetic Resonance Imaging
Male
Mutation
Neoplasms, Multiple Primary/diagnosis
Neoplastic Syndromes, Hereditary/diagnosis
Paraganglioma/diagnosis
Positron Emission Tomography Computed Tomography
Succinate Dehydrogenase/genetics
Thoracic Neoplasms/diagnosis

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10.1016/j.athoracsur.2019.05.037

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title = "Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier",

abstract = "Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.",

keywords = "Adult, DNA Mutational Analysis, DNA, Neoplasm/genetics, Head and Neck Neoplasms/diagnosis, Humans, Magnetic Resonance Imaging, Male, Mutation, Neoplasms, Multiple Primary/diagnosis, Neoplastic Syndromes, Hereditary/diagnosis, Paraganglioma/diagnosis, Positron Emission Tomography Computed Tomography, Succinate Dehydrogenase/genetics, Thoracic Neoplasms/diagnosis",

author = "Rijken, {Johannes A} and {de Vos}, Berry and Leemans, {C Ren{\'e}} and Zwezerijnen, {G J C Ben} and {de Graaf}, Pim and Hensen, {Erik F} and Dreijerink, {Koen M A} and Chris Dickhoff and Petr Symersky",

note = "Publisher Copyright: {\textcopyright} 2020 The Society of Thoracic Surgeons",

year = "2020",

month = feb,

doi = "10.1016/j.athoracsur.2019.05.037",

language = "English",

volume = "109",

pages = "e87--e90",

journal = "The Annals of Thoracic Surgery",

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T1 - Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

AU - Rijken, Johannes A

AU - de Vos, Berry

AU - Leemans, C René

AU - Zwezerijnen, G J C Ben

AU - de Graaf, Pim

AU - Hensen, Erik F

AU - Dreijerink, Koen M A

AU - Dickhoff, Chris

AU - Symersky, Petr

PY - 2020/2

Y1 - 2020/2

N2 - Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.

AB - Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.

KW - Adult

KW - DNA Mutational Analysis

KW - DNA, Neoplasm/genetics

KW - Head and Neck Neoplasms/diagnosis

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Mutation

KW - Neoplasms, Multiple Primary/diagnosis

KW - Neoplastic Syndromes, Hereditary/diagnosis

KW - Paraganglioma/diagnosis

KW - Positron Emission Tomography Computed Tomography

KW - Succinate Dehydrogenase/genetics

KW - Thoracic Neoplasms/diagnosis

U2 - 10.1016/j.athoracsur.2019.05.037

DO - 10.1016/j.athoracsur.2019.05.037

M3 - Article

C2 - 31279790

SN - 0003-4975

VL - 109

SP - e87-e90

JO - The Annals of Thoracic Surgery

JF - The Annals of Thoracic Surgery

IS - 2

ER -

Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Abstract

Keywords

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