TY - JOUR
T1 - Management of liver sinusoidal obstruction syndrome/veno-occlusive disease in adults
T2 - a 2025 perspective from an international expert group
AU - Larue, Marion
AU - Malard, Florent
AU - Alaskar, Ahmed S
AU - Aljurf, Mahmoud
AU - Arat, Mutlu
AU - Balsat, Marie
AU - Baron, Frédéric
AU - Basak, Grzegorz
AU - Bazarbachi, Ali
AU - Bonifazi, Francesca
AU - Brissot, Eolia
AU - Ciceri, Fabio
AU - Corbacioglu, Selim
AU - Dignan, Fiona
AU - Huynh, Anne
AU - Kenyon, Michelle
AU - Kuball, Jürgen
AU - Lachance, Silvy
AU - Masszi, Tamas
AU - Nagler, Arnon
AU - Okamoto, Shinichiro
AU - Pagliuca, Antonio
AU - Ruggeri, Annalisa
AU - Ruutu, Tapani
AU - Yakoub-Agha, Ibrahim
AU - Ye, Yishan
AU - Duarte, Rafael F
AU - Perić, Zinaida
AU - Carreras, Enric
AU - Mohty, Mohamad
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Limited 2025.
PY - 2025/7
Y1 - 2025/7
N2 - Sinusoidal obstruction syndrome (SOS) formerly known as Veno-occlusive disease (VOD) is a potentially fatal complication that occurs mainly after haematopoietic cell transplantation, especially allogeneic transplantation. The liver is the principal organ affected, though other organs, such as the lungs, may also be involved to a lesser extent. The condition is characterised by obstruction of the hepatic venules, leading to sinusoidal congestion, hepatic ischaemia and, in severe cases, fulminant liver failure. Recent refined diagnostic criteria, published by the European Society for Blood and Marrow Transplantation in 2023, provide a more accurate method of detecting SOS/VOD, allowing earlier intervention and better stratification of patients according to the severity of their disease. This article focuses on liver SOS/VOD and discussing key risk factors, new diagnostic methods and therapeutic strategies, with an emphasis on the early use of defibrotide, which remains the reference treatment for severe SOS/VOD.
AB - Sinusoidal obstruction syndrome (SOS) formerly known as Veno-occlusive disease (VOD) is a potentially fatal complication that occurs mainly after haematopoietic cell transplantation, especially allogeneic transplantation. The liver is the principal organ affected, though other organs, such as the lungs, may also be involved to a lesser extent. The condition is characterised by obstruction of the hepatic venules, leading to sinusoidal congestion, hepatic ischaemia and, in severe cases, fulminant liver failure. Recent refined diagnostic criteria, published by the European Society for Blood and Marrow Transplantation in 2023, provide a more accurate method of detecting SOS/VOD, allowing earlier intervention and better stratification of patients according to the severity of their disease. This article focuses on liver SOS/VOD and discussing key risk factors, new diagnostic methods and therapeutic strategies, with an emphasis on the early use of defibrotide, which remains the reference treatment for severe SOS/VOD.
UR - https://www.scopus.com/pages/publications/105003194249
U2 - 10.1038/s41409-025-02598-y
DO - 10.1038/s41409-025-02598-y
M3 - Article
C2 - 40263636
SN - 0268-3369
VL - 60
SP - 1002
EP - 1008
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 7
ER -