Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study

Marc Dirix; Tine Van Becelaere; Lizanne Berkenbosch; Robertine Van Baren; Rene M. Wijnen; Marc H. Wijnen; David C. Van Der Zee; Hugo A. Heij; Joep P M Derikx; L. W Ernest Van Heurn

doi:10.1016/j.jpedsurg.2014.07.014

Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study

Marc Dirix
, Tine Van Becelaere
, Lizanne Berkenbosch
, Robertine Van Baren
, Rene M. Wijnen
, Marc H. Wijnen
, David C. Van Der Zee
, Hugo A. Heij
, Joep P M Derikx
, L. W Ernest Van Heurn^*

^*Corresponding author for this work

Department of Pediatric surgery

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Background/purpose The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

Original language	English
Pages (from-to)	462-464
Number of pages	3
Journal	Journal of Pediatric Surgery
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.jpedsurg.2014.07.014
Publication status	Published - 1 Mar 2015

Keywords

Currarino syndrome
Malignancy
Sacrococcygeal teratoma

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10.1016/j.jpedsurg.2014.07.014

71-mainFinal published version, 223 KBLicence: Taverne

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Dirix, M., Van Becelaere, T., Berkenbosch, L., Van Baren, R., Wijnen, R. M., Wijnen, M. H., Van Der Zee, D. C., Heij, H. A., Derikx, J. P. M., & Van Heurn, L. W. E. (2015). Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study. Journal of Pediatric Surgery, 50(3), 462-464. https://doi.org/10.1016/j.jpedsurg.2014.07.014

@article{94cce73f85824bd1907caf35fc4c9460,

title = "Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study",

abstract = "Background/purpose The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80\% and 58\% after one and two years in SCT versus 100\% after two years in CS, p = 0.017) Conclusions In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.",

keywords = "Currarino syndrome, Malignancy, Sacrococcygeal teratoma",

author = "Marc Dirix and \{Van Becelaere\}, Tine and Lizanne Berkenbosch and \{Van Baren\}, Robertine and Wijnen, \{Rene M.\} and Wijnen, \{Marc H.\} and \{Van Der Zee\}, \{David C.\} and Heij, \{Hugo A.\} and Derikx, \{Joep P M\} and \{Van Heurn\}, \{L. W Ernest\}",

year = "2015",

month = mar,

day = "1",

doi = "10.1016/j.jpedsurg.2014.07.014",

language = "English",

volume = "50",

pages = "462--464",

journal = "Journal of Pediatric Surgery",

issn = "0022-3468",

publisher = "W.B. Saunders",

number = "3",

}

Dirix, M, Van Becelaere, T, Berkenbosch, L, Van Baren, R, Wijnen, RM, Wijnen, MH , Van Der Zee, DC, Heij, HA, Derikx, JPM & Van Heurn, LWE 2015, 'Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study', Journal of Pediatric Surgery, vol. 50, no. 3, pp. 462-464. https://doi.org/10.1016/j.jpedsurg.2014.07.014

TY - JOUR

T1 - Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome

T2 - A comparative study

AU - Dirix, Marc

AU - Van Becelaere, Tine

AU - Berkenbosch, Lizanne

AU - Van Baren, Robertine

AU - Wijnen, Rene M.

AU - Wijnen, Marc H.

AU - Van Der Zee, David C.

AU - Heij, Hugo A.

AU - Derikx, Joep P M

AU - Van Heurn, L. W Ernest

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background/purpose The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

AB - Background/purpose The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

KW - Currarino syndrome

KW - Malignancy

KW - Sacrococcygeal teratoma

UR - https://www.scopus.com/pages/publications/84924019572

U2 - 10.1016/j.jpedsurg.2014.07.014

DO - 10.1016/j.jpedsurg.2014.07.014

M3 - Article

C2 - 25746708

AN - SCOPUS:84924019572

SN - 0022-3468

VL - 50

SP - 462

EP - 464

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

IS - 3

ER -

Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study

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